Phuangchoei Prapinpa, Chotiyaputta Watcharasak, Chayakulkeeree Methee
J Med Assoc Thai. 2015 Mar;98(3):226-31.
Hepatitis B virus (HBV) and hepatitis C virus (HCV) share a common route of transmission with human immunodeficiency virus (HIV). HIV co-infected with HBV or HCV was associated with a progression to severe liver disease, increased risk of hepatotoxicity from antiretroviral therapy and reduced survival. Data regarding HBV and HCV infection in HIV-positive individuals in Thailand is limited.
To investigate the prevalence and clinical characteristics of HBV and HCV infection in HIV-infected patients in Siriraj Hospital.
A retrospective study was conducted in adult HIV-positive followed up at the Infectious Disease Clinic, Siriraj Hospital. Prevalence of HBV and HCV infections and clinical characteristics were analyzed.
250 HIV-positive patients were enrolled, mean age was 38.8 years and 57.2% were male. HBV infection was found in 6.5% (15/231), and HCV infection was 7.7% (17/222). One patient had both HBV and HCV infections. In multivariate analysis, factors associated with either HBV or HCV co-infection included male gender (77.4% vs. 55%; p 0.008), history of salmonellosis (9.7% vs. 2.5%; p 0.042) or elevated serum alanine aminotransferase (ALT) level (34 U/L vs. 25 U/L; p 0.018). Factors associated with HBV infection, compared with those without hepatitis virus infection, included male gender (86.7% vs. 56%; p 0.038), history of salmonellosis (20% vs. 2.3%; p 0.005), elevated serum ALT level (42 U/L vs. 25 U/L; p 0.012) and low CD4 percent (1.05% vs. 5.02%; p 0.04). In this study, we did not find any factor associated with HCV infection in HIV patients.
The prevalence of HBV and HCV infection in HIV-infected Thai patients is significant. Male gender, history of salmonellosis, elevated serum ALT levels, and low CD4 percent are associated with HBV co-infection.
乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）与人类免疫缺陷病毒（HIV）具有共同的传播途径。HIV与HBV或HCV合并感染与严重肝病进展、抗逆转录病毒治疗导致肝毒性风险增加及生存率降低有关。泰国HIV阳性个体中HBV和HCV感染的数据有限。
调查诗里拉吉医院HIV感染患者中HBV和HCV感染的患病率及临床特征。
对在诗里拉吉医院传染病诊所接受随访的成年HIV阳性患者进行回顾性研究。分析HBV和HCV感染的患病率及临床特征。
纳入250例HIV阳性患者，平均年龄38.8岁，男性占57.2%。HBV感染率为6.5%（15/231），HCV感染率为7.7%（17/222）。1例患者同时感染HBV和HCV。多因素分析显示，与HBV或HCV合并感染相关的因素包括男性（77.4%对55%；p = 0.008）、沙门氏菌病病史（9.7%对2.5%；p = 0.042）或血清丙氨酸氨基转移酶（ALT）水平升高（34 U/L对25 U/L；p = 0.018）。与未感染肝炎病毒的患者相比，与HBV感染相关的因素包括男性（86.7%对56%；p = 0.038）、沙门氏菌病病史（20%对2.3%；p = 0.005）、血清ALT水平升高（42 U/L对25 U/L；p = 0.012）及CD4百分比降低（1.05%对5.02%；p = 0.04）。在本研究中，未发现与HIV患者HCV感染相关的任何因素。
泰国HIV感染患者中HBV和HCV感染的患病率较高。男性、沙门氏菌病病史、血清ALT水平升高及CD4百分比降低与HBV合并感染有关。
