白质中T1的微观结构相关性。
The microstructural correlates of T1 in white matter.
作者信息
Harkins Kevin D, Xu Junzhong, Dula Adrienne N, Li Ke, Valentine William M, Gochberg Daniel F, Gore John C, Does Mark D
机构信息
Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, USA.
Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee, USA.
出版信息
Magn Reson Med. 2016 Mar;75(3):1341-5. doi: 10.1002/mrm.25709. Epub 2015 Apr 28.
Abstract
PURPOSE
Several studies have shown strong correlations between myelin content and T1 within the brain, and have even suggested that T1 can be used to estimate myelin content. However, other micro-anatomical features such as compartment size are known to affect longitudinal relaxation rates, similar to compartment size effects in porous media.
METHODS
T1 measurements were compared with measured or otherwise published axon size measurements in white matter tracts of the rat spinal cord, rat brain, and human brain.
RESULTS
In both ex vivo and in vivo studies, correlations were present between the relaxation rate 1/T1 and axon size across regions of rat spinal cord with nearly equal myelin content.
CONCLUSION
While myelination is likely the dominant determinant of T1 in white matter, variations in white matter microstructure, independent of myelin volume fraction, may also be reflected in T1 differences between regions or subjects.
摘要
目的
多项研究表明脑内髓磷脂含量与T1之间存在强相关性，甚至有人提出T1可用于估计髓磷脂含量。然而，其他微观解剖特征，如隔室大小，已知会影响纵向弛豫率，类似于多孔介质中的隔室大小效应。
方法
将大鼠脊髓、大鼠脑和人脑白质束中的T1测量值与测量的或以其他方式发表的轴突大小测量值进行比较。
结果
在体外和体内研究中，在髓磷脂含量几乎相等的大鼠脊髓区域，弛豫率1/T1与轴突大小之间均存在相关性。
结论
虽然髓鞘形成可能是白质中T1的主要决定因素，但白质微观结构的变化，独立于髓磷脂体积分数，也可能反映在不同区域或受试者之间的T1差异中。
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