Robles Claudia, Casabonne Delphine, Benavente Yolanda, Costas Laura, Gonzalez-Barca Eva, Aymerich Marta, Campo Elias, Tardon Adonina, Jiménez-Moleón José J, Castaño-Vinyals Gemma, Dierssen-Sotos Trinidad, Michel Angelika, Kranz Lena, Aragonés Nuria, Pollan Marina, Kogevinas Manolis, Pawlita Michael, de Sanjose Silvia
Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain.
Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d'Oncologia - Catalan Institute of Oncology, IDIBELL, 08908 L'Hospitalet de Llobregat, Barcelona, Spain.
J Gen Virol. 2015 Aug;96(8):2286-2292. doi: 10.1099/vir.0.000167. Epub 2015 Apr 28.
Merkel cell polyomavirus (MCPyV) has been suspected to cause chronic lymphocytic leukaemia (CLL) but previous data are inconsistent. We measured seroreactivities of nine polyomaviruses (MCPyV, BKPyV, JCPyV, LPyV, KIPyV, WUPyV, HPyV-6, HPyV-7 and TSPyV) in 359 CLL cases and 370 controls using bead-based multiplex serology technology. We additionally tested two herpesviruses (HSV-1 and CMV). Associations between disease and viral seroreactivities were assessed using logistic regression. All human viruses showed high seroprevalences (69-99%) against structural proteins in controls but significantly lower viral seroprevalences in cases (58-94%; OR range = 0.21-0.70, P value < 0.05), except for MCPyV (OR = 0.79, 95% CI = 0.54-1.16). Lower seroreactivity levels were observed among CLL subjects, with significant differences already observed at early stages of disease, unrelated to treatment status. Seroreactivities against polyomavirus related oncoproteins were almost null. Our data suggest no association for MCPyV polyomavirus with CLL development and an unlikely association for other polyomaviruses tested.
默克尔细胞多瘤病毒（MCPyV）曾被怀疑可引发慢性淋巴细胞白血病（CLL），但既往数据并不一致。我们采用基于微珠的多重血清学技术，检测了359例CLL患者及370名对照者体内9种多瘤病毒（MCPyV、BKPyV、JCPyV、LPyV、KIPyV、WUPyV、HPyV - 6、HPyV - 7和TSPyV）的血清反应性。我们还检测了两种疱疹病毒（HSV - 1和CMV）。采用逻辑回归评估疾病与病毒血清反应性之间的关联。所有人类病毒在对照者体内针对结构蛋白均显示出较高的血清阳性率（69 - 99%），但在患者体内病毒血清阳性率显著较低（58 - 94%；OR范围 = 0.21 - 0.70，P值 < 0.05），MCPyV除外（OR = 0.79，95% CI = 0.54 - 1.16）。在CLL患者中观察到较低的血清反应性水平，在疾病早期就已观察到显著差异，且与治疗状态无关。针对多瘤病毒相关癌蛋白的血清反应性几乎为零。我们的数据表明MCPyV多瘤病毒与CLL的发生无关联，且所检测的其他多瘤病毒也不太可能有关联。
