Narod S A, Kharazmi E, Fallah M, Sundquist K, Hemminki K
Women's College Research Institute, Women's College Hospital, Toronto, Canada.
Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Clin Genet. 2016 Mar;89(3):332-5. doi: 10.1111/cge.12604. Epub 2015 May 21.
We aimed to estimate the 15-year and lifetime risks of contralateral breast cancer in breast cancer patients according to the age of diagnosis of the first cancer and the history of breast cancer in the mother. The risks of contralateral breast cancer were estimated for all 78,775 breast cancer patients in the Swedish Family-Cancer Database (age at diagnosis of first breast cancer <70 years). The risk of experiencing a contralateral breast cancer within 15 years of diagnosis was 8.4% [95% confidence interval (CI): 8.1-8.7%] for women with an unaffected mother, was 12% (95%CI: 11-13%) for a woman with a mother with unilateral breast cancer and was 13% (95%CI: 9.5-17%) for women with a mother with bilateral breast cancer. In early-onset diagnosed women (<50 years) with an unaffected mother, the risk of contralateral breast cancer until age 80 was 23% (95%CI: 20-26%) and for late-onset (50-69 years) diagnosed women it was 17% (95%CI: 14-21%). In a woman with a mother with an early-onset unilateral breast cancer, risk of contralateral breast cancer by age 80 was 35% (95%CI: 25-46%). Women with a mother with early-onset bilateral breast cancer had 31% (95%CI: 12-67%) lifetime risk of contralateral breast cancer. The risk of contralateral breast cancer is higher for daughters of breast cancer patients than for daughters of women without breast cancer. Maternal cancer history and age at onset of first breast cancer in women should be taken into account when counseling breast cancer patients about their risk of contralateral breast cancer.
我们旨在根据首次患癌的诊断年龄和母亲的乳腺癌病史，估算乳腺癌患者对侧乳腺癌的15年和终生风险。在瑞典家族癌症数据库中，对所有78775例乳腺癌患者（首次乳腺癌诊断年龄<70岁）的对侧乳腺癌风险进行了估算。母亲未患乳腺癌的女性，在诊断后15年内发生对侧乳腺癌的风险为8.4%[95%置信区间（CI）：8.1 - 8.7%]；母亲患单侧乳腺癌的女性为12%（95%CI：11 - 13%）；母亲患双侧乳腺癌的女性为13%（95%CI：9.5 - 17%）。在母亲未患乳腺癌且早发诊断（<50岁）的女性中，至80岁时对侧乳腺癌的风险为23%（95%CI：20 - 26%）；晚发诊断（50 - 69岁）的女性为17%（95%CI：14 - 21%）。母亲患有早发单侧乳腺癌的女性，至80岁时对侧乳腺癌的风险为35%（95%CI：25 - 46%）。母亲患有早发双侧乳腺癌的女性，对侧乳腺癌的终生风险为31%（95%CI：12 - 67%）。乳腺癌患者的女儿发生对侧乳腺癌的风险高于无乳腺癌女性的女儿。在为乳腺癌患者提供关于对侧乳腺癌风险的咨询时，应考虑女性的母亲癌症病史和首次患乳腺癌的发病年龄。
