Dehghani Mehdi, Haddadi Sara, Vojdani Reza
Department of Hematology Oncology, Shiraz University of Medical Sciences, Hematology research center, Iran E-mail :
Asian Pac J Cancer Prev. 2015;16(8):3551-7. doi: 10.7314/apjcp.2015.16.8.3551.
Non-Hodgkin's lymphoma (NHL) is a heterogeneous type of neoplasm of the lymphatic system. To have a more accurate and early diagnosis we need to know signs, symptoms and complications of lymphoma in early stages besides pathology and immunohistochemistry.
This prospective study included 110 cases of NHL that were followed since February 2012 till November 2013. Biopsies were taken from all the patients besides bone marrow study. Signs and symptoms were categorized into "B" symptoms, general, lymphadenopathy and extranodal involvement and we compared the frequencies by stage and grade.
Of 110 cases, 88.9% had B-cell and 11.1% T-cell type with mean age 48.5±18.6 years. "B" symptoms and lymphadenopathy were more common in men. Cervical lymphadenopathy was the most common sign (44.8%). and hematologic, bone marrow, bone and neurologic lesions were the most common complications. All complications were more common in males. "B" symptoms were seen mostly in stage III, general signs and symptoms in stage IV, and lymphadenopathy in stage II. Intermediate grade was also the most common in all signs and symptoms. In this study 12 (10.9%) patients had relapse, with neurologic and bone marrow as the most common sites of tumor recurrence.
There is a meaningful relationship between male gender for NHL and anemia that can be due in part to higher incidence of bone marrow involvement and stage IV disease in male cases. We also found a strong relationship between low grade NHL and age. On the other hand extranodal involvement is more common in female groups.
非霍奇金淋巴瘤（NHL）是淋巴系统的一种异质性肿瘤类型。为了进行更准确的早期诊断，除了病理和免疫组化外，我们还需要了解淋巴瘤早期的体征、症状和并发症。
这项前瞻性研究纳入了110例NHL患者，从2012年2月至2013年11月对其进行随访。除了骨髓检查外，还对所有患者进行了活检。体征和症状分为“B”症状、一般症状、淋巴结病和结外受累，我们按分期和分级比较了其发生率。
110例患者中，88.9%为B细胞型，11.1%为T细胞型，平均年龄48.5±18.6岁。“B”症状和淋巴结病在男性中更为常见。颈部淋巴结病是最常见的体征（44.8%），血液学、骨髓、骨骼和神经病变是最常见的并发症。所有并发症在男性中更为常见。“B”症状多见于Ⅲ期，一般体征和症状见于Ⅳ期，淋巴结病见于Ⅱ期。中级在所有体征和症状中也最为常见。在本研究中，12例（10.9%）患者复发，神经和骨髓是肿瘤复发最常见的部位。
NHL男性患者与贫血之间存在显著关系，这可能部分归因于男性病例中骨髓受累和Ⅳ期疾病的发生率较高。我们还发现低级别NHL与年龄之间存在密切关系。另一方面，结外受累在女性群体中更为常见。
