Yalbuzdag Seniz Akcay, Sarifakioglu Banu, Afsar Sevgi Ikbali, Celik Canan, Can Aslı, Yegin Tugba, Senturk Burcu, Guzelant Aliye Yildirim
Physical Medicine and Rehabilitation Department, Izmir Bozyaka Education and Research Hospital, Izmir, Turkey.
Physical Medicine and Rehabilitation Department, Namık Kemal University, Tekirdag, Turkey.
J Stroke Cerebrovasc Dis. 2015 Jul;24(7):1479-86. doi: 10.1016/j.jstrokecerebrovasdis.2015.03.007. Epub 2015 Apr 25.
In recent years, vitamin D deficiency has been suggested as a risk factor for ischemic stroke and stroke severity in both animal models and clinical studies. In this retrospective study, we investigated the relationship between 25-hydroxyvitamin D [25(OH)D] levels and functional outcomes in stroke patients during neurological rehabilitation program. We also investigated whether there is an association between 25(OH)D levels and cognitive impairment.
The study included the medical records of 120 stroke patients who participated in a neurological rehabilitation program. The motor and cognitive components of the Functional Independence Measurements of all patients at admission and discharge were recorded. The Functional Ambulatory Scale was used to assess motor functional status, and the Turkish-validated version of the minimental state examination test was used to assess cognitive status.
A significant correlation was found between 25(OH)D level and cognitive impairment among patients who had ischemic strokes. High levels of 25(OH)D were associated with greater functional gain during the rehabilitation program in both ischemic stroke patients and hemorrhagic stroke patients.
High 25(OH)D levels might be associated with greater functional improvement and with less cognitive impairment in stroke patients.
近年来，在动物模型和临床研究中，维生素D缺乏已被认为是缺血性中风及中风严重程度的一个风险因素。在这项回顾性研究中，我们调查了在神经康复计划期间，中风患者的25-羟基维生素D[25(OH)D]水平与功能预后之间的关系。我们还调查了25(OH)D水平与认知障碍之间是否存在关联。
该研究纳入了120名参与神经康复计划的中风患者的病历。记录了所有患者入院和出院时功能独立性测量的运动和认知部分。使用功能步行量表评估运动功能状态，并使用经土耳其验证的简易精神状态检查测试评估认知状态。
在缺血性中风患者中，发现25(OH)D水平与认知障碍之间存在显著相关性。在缺血性中风患者和出血性中风患者中，高25(OH)D水平均与康复计划期间更大的功能改善相关。
高25(OH)D水平可能与中风患者更大的功能改善和较少的认知障碍相关。
