Tran Thanh-Nga Trinh, Hoang Minh Van, Phan Quynh-Anh Ngoc, Phung Thuy L, Purschke Martin, Ferinelli William A, Sabir Sameer, Ziegler Andrew, Nelson Stuart, Anderson R Rox
Cutaneous Biology Research Center, Boston, Massachusetts, USA.
University of Medicine and Pharmacy, Ho Chi Minh City, Virtnam.
Semin Cutan Med Surg. 2015 Mar;34(1):42-7. doi: 10.12788/j.sder.2015.0141.
Radiation injury to the skin is a major source of dysfunction, disfigurement, and complications for thousands of patients undergoing adjunctive treatment for internal cancers. Despite the great potential for affecting quality of life, radiation injury has received little attention from dermatologists and is primarily being managed by radiation oncologists. During our volunteer work in Vietnam, we encountered numerous children with significant scarring and depigmentation of skin from the outdated use of radioactive phosphorus P32 in the treatment of hemangiomas. This dangerous practice has left thousands of children with significant fibrosis and disfigurement. Currently, there is no treatment for radiation dermatitis. Here, we report a case series using the combination of laser treatment, including pulsed-dye laser, fractional CO2 laser, and epidermal grafting to improve the appearance and function of the radiation scars in these young patients. We hope that by improving the appearance and function of these scars, we can improve the quality of life for these young patients and potentially open up a new avenue of treatment for cancer patients affected with chronic radiation dermatitis, potentially improving their range of motion, cosmesis, and reducing their risk of secondary skin malignancies.
皮肤辐射损伤是数千名接受内癌辅助治疗患者功能障碍、毁容和并发症的主要来源。尽管对生活质量有很大影响，但辐射损伤很少受到皮肤科医生的关注，主要由放射肿瘤学家进行处理。在我们在越南的志愿工作中，我们遇到了许多儿童，他们因过去使用放射性磷P32治疗血管瘤而出现严重的皮肤瘢痕和色素脱失。这种危险的做法使数千名儿童出现严重的纤维化和毁容。目前，尚无治疗放射性皮炎的方法。在此，我们报告一个病例系列，使用包括脉冲染料激光、超脉冲二氧化碳激光和表皮移植在内的激光治疗组合，以改善这些年轻患者辐射瘢痕的外观和功能。我们希望通过改善这些瘢痕的外观和功能，能够提高这些年轻患者的生活质量，并有可能为受慢性放射性皮炎影响的癌症患者开辟一条新的治疗途径，潜在地改善他们的活动范围、美容效果，并降低他们发生继发性皮肤恶性肿瘤的风险。
