Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Department of Dermatology, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Lasers Surg Med. 2023 Jan;55(1):82-88. doi: 10.1002/lsm.23617. Epub 2022 Nov 9.
Chronic radiation fibrosis (CRF) is a long-term sequala of radiation therapy that has a significant impact on patient quality of life. There is no standard of care or single therapeutic modality that has been found to be consistently effective.
To describe our experience using fractional 10,600 nm carbon dioxide (CO ) laser therapy and vascular laser therapy in a series of patients with CRF.
Patients presenting to the dermatology service for CRF were evaluated for laser therapy eligibility. Patients were eligible if they had a clinical diagnosis of CRF confirmed by physical examination.
We identified five patients with CRF treated with fractional ablative CO laser and vascular laser. Patients were a median age of 57 years old, and the amount of time between the initiation of radiotherapy and laser treatment ranged between 3 months and 40 years. The satisfactory response was achieved in all cases.
Lack of standardized laser protocol, small sample size, lack of a control group, different anatomical locations CONCLUSION: Fractional ablative and vascular laser therapy may serve as an additional treatment for CRF, leading to functional improvements.
慢性放射性纤维化（CRF）是放射治疗的一种长期后遗症，对患者的生活质量有重大影响。目前尚无标准的治疗方法或单一的治疗方式被证明始终有效。
描述我们在一系列慢性放射性纤维化患者中使用分段 10600nm 二氧化碳（CO ）激光治疗和血管激光治疗的经验。
向皮肤科就诊的慢性放射性纤维化患者评估激光治疗的适应证。如果患者通过体格检查临床诊断为 CRF，则符合入组标准。
我们共确定了 5 例接受分段消融 CO 激光和血管激光治疗的慢性放射性纤维化患者。患者的中位年龄为 57 岁，放射治疗和激光治疗之间的时间间隔范围为 3 个月至 40 年。所有病例均取得了满意的疗效。
缺乏标准化的激光方案、样本量小、缺乏对照组、不同的解剖部位。
分段消融和血管激光治疗可能是慢性放射性纤维化的一种附加治疗方法，可改善功能。
