Hart R P, Rose C S, Hamer R M
Medical College of Virginia, Virginia Commonwealth University, Richmond.
J Clin Exp Neuropsychol. 1989 Dec;11(6):933-43. doi: 10.1080/01688638908400946.
Neuropsychological functioning was measured in 31 male workers exposed to cadmium in a refrigerator coil manufacturing plant. Workers with high urinary cadmium levels performed less well than did those with low urinary cadmium levels on measures of attention, psychomotor speed, and memory. There were modest correlations between one of two biologic measures of cadmium exposure and neuropsychological performance. The neuropsychological impairments cannot readily be attributed to exposure to other neurotoxins, alcohol intake, CNS effects of renal dysfunction, or psychological distress. Cadmium body burden has previously been related to intelligence and school achievement of children; this study would appear to be the first to suggest that occupational exposure to cadmium is associated with cognitive impairment in adults. Cadmium interferes with several important nervous system functions, but the mechanisms of neurotoxicity remain uncertain.
对一家冰箱盘管制造工厂的31名接触镉的男性工人进行了神经心理学功能测试。在注意力、心理运动速度和记忆测试中，尿镉水平高的工人表现不如尿镉水平低的工人。镉暴露的两种生物学指标之一与神经心理学表现之间存在适度的相关性。神经心理学损伤不易归因于接触其他神经毒素、饮酒、肾功能不全的中枢神经系统影响或心理困扰。镉的身体负担此前已与儿童的智力和学业成绩相关；这项研究似乎是首次表明职业性镉暴露与成年人的认知障碍有关。镉会干扰几种重要的神经系统功能，但神经毒性机制仍不确定。
