Charkiewicz Angelika Edyta, Omeljaniuk Wioleta Justyna, Nowak Karolina, Garley Marzena, Nikliński Jacek
Department of Clinical Molecular Biology, Faculty of Medicine with the Division of Dentistry and Division of Medical Education in English, Medical University of Białystok, 15-269 Białystok, Poland.
Department of Analysis and Bioanalysis of Medicines, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Białystok, 15-222 Białystok, Poland.
Molecules. 2023 Sep 14;28(18):6620. doi: 10.3390/molecules28186620.
Cadmium (Cd) is a ductile metal in the form of a blueish or silvery-white powder. It is naturally found in soil (about 0.2 mg/kg), minerals, and water. Cd belongs to the group of toxic, carcinogenic, and stimulating elements. Its biological half-life in the human body ranges from 16 to even 30 years on average. Some lung diseases (such as emphysema, asthma, and bronchitis) and high blood pressure are thought to be related to slow poisoning. The symptoms of cadmium poisoning may vary depending on the time of exposure, the type of diet, and the age and health status of the exposed people. For non-smokers and non-occupational exposures, the only source of exposure is diet. The FAO/WHO recommends that the tolerable cadmium intake for an adult is approximately 0.4-0.5 mg/week (60-70 µg per day). Cadmium is primarily absorbed through the respiratory system (about 13-19% of Cd from the air), but it can also enter through the digestive system (about 10-44%), when dust is mixed and swallowed with saliva. The amount of accumulated Cd ranges from 0.14 to 3.2 ppm in muscles, 1.8 ppm in bones, and 0.0052 ppm in the blood. People who are most frequently exposed to heavy metals should be continuously monitored in order to maintain a healthy lifestyle, as well as to implement effective preventive measures and improve public health.
镉(Cd)是一种呈蓝灰色或银白色粉末状的可延展金属。它天然存在于土壤(约0.2毫克/千克)、矿物质和水中。镉属于有毒、致癌和刺激性元素类别。其在人体中的生物半衰期平均为16年甚至可达30年。一些肺部疾病(如肺气肿、哮喘和支气管炎)以及高血压被认为与慢性中毒有关。镉中毒的症状可能因接触时间、饮食类型以及接触者的年龄和健康状况而有所不同。对于非吸烟者和非职业性接触,唯一的接触源是饮食。粮农组织/世界卫生组织建议成年人的镉耐受摄入量约为每周0.4 - 0.5毫克(每天60 - 70微克)。镉主要通过呼吸系统吸收(空气中镉的13 - 19%),但当灰尘与唾液混合并被吞咽时,它也可通过消化系统进入(约10 - 44%)。镉在肌肉中的累积量为0.14至3.2 ppm,在骨骼中为1.8 ppm,在血液中为0.0052 ppm。为了保持健康的生活方式、实施有效的预防措施并改善公众健康,应持续监测最常接触重金属的人群。