一种来自单瓣李叶绣线菊嫩枝的新酚苷。

A new phenolic glycoside from Spiraea prunifolia var. simpliciflora twigs.

作者信息

Jang Sung Wan, Suh Won Se, Kim Chung Sub, Kim Ki Hyun, Lee Kang Ro

机构信息

Natural Product Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon, 440-746, Korea.

出版信息

Arch Pharm Res. 2015 Nov;38(11):1943-51. doi: 10.1007/s12272-015-0610-y. Epub 2015 Apr 30.

DOI:10.1007/s12272-015-0610-y

PMID:25925344

Abstract

The phytochemical investigation of the methanol extract from the twigs of Spiraea prunifolia var. simpliciflora (Rosaceae) using column chromatography led to the isolation of a new phenol glycoside, 1-O-(E)-caffeoyl-2-O-p-(E)-coumaroyl-β-D-glucopyranose (1), together with 16 known phenolic compounds (2-17). The structure of this new compound was elucidated by analysis of spectroscopic data including 1D, 2D nuclear magnetic resonance and HR-FAB-MS data. The isolated compounds were tested for cytotoxicity against four human tumor cell lines in vitro using the sulforhodamine B bioassay.

摘要

采用柱色谱法对单瓣李叶绣线菊（蔷薇科）嫩枝的甲醇提取物进行植物化学研究，从中分离出一种新的酚苷，1-O-(E)-咖啡酰基-2-O-p-(E)-香豆酰基-β-D-吡喃葡萄糖苷（1），以及16种已知的酚类化合物（2 - 17）。通过对包括一维、二维核磁共振和高分辨快原子轰击质谱数据在内的光谱数据进行分析，阐明了这种新化合物的结构。使用磺酰罗丹明B生物测定法，对分离得到的化合物进行了体外对四种人类肿瘤细胞系的细胞毒性测试。