Guo Ruifeng, Gavino Alde Carlo P
From the Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City (Dr Guo); and the Department of Dermatology, University of Texas Southwestern-Austin, Austin (Dr Gavino).
Arch Pathol Lab Med. 2015 May;139(5):683-6. doi: 10.5858/arpa.2013-0334-RS.
Angiolymphoid hyperplasia with eosinophilia (ALHE), also named epithelioid hemangioma (EH), is an inflamed vascular tumefaction of uncertain pathogenesis, characterized by proliferation of histiocytoid endothelial cells with prominent lymphocytic and eosinophilic infiltration. Although considered a benign condition, it may recur in up to one-third of cases in the absence of complete surgical excision. The pathogenesis of ALHE/EH is still controversial. However, reaction to trauma and arteriovenous shunting are considered relevant. Histologically, ALHE/EH may be differentiated from other vascular neoplasms by its several unique characteristics including prominent proliferation of plump endothelial cells, and accompanying eosinophilic and lymphocytic inflammation, often with formation of lymphoid follicles. Surgery is the mainstay of treatment and various other treatment strategies have been used with varying results.
伴有嗜酸性粒细胞增多的血管淋巴样增生（ALHE），也称为上皮样血管瘤（EH），是一种发病机制不明的炎症性血管肿物，其特征为组织细胞样内皮细胞增生，并伴有显著的淋巴细胞和嗜酸性粒细胞浸润。尽管被认为是一种良性疾病，但在未完全手术切除的情况下，高达三分之一的病例可能会复发。ALHE/EH的发病机制仍存在争议。然而，创伤反应和动静脉分流被认为与之相关。在组织学上，ALHE/EH可通过其几个独特特征与其他血管肿瘤相鉴别，这些特征包括丰满的内皮细胞显著增生，以及伴随的嗜酸性粒细胞和淋巴细胞炎症，常伴有淋巴滤泡形成。手术是主要的治疗方法，也使用了各种其他治疗策略，效果各异。
