细胞外基质诱导乳腺癌细胞正常化的潜在机制。
A potential mechanism for extracellular matrix induction of breast cancer cell normality.
机构信息
School of Medical Diagnostic and Translational Sciences, College of Health Sciences, Old Dominion University, Norfolk, VA, 23529, USA.
Mammary Stem Cell Biology Section, CCBB, Center for Cancer Research, NCI, Bethesda, MD, 20892, USA.
出版信息
Breast Cancer Res. 2014 Feb 17;16(1):302. doi: 10.1186/bcr3617.
Abstract
Extracellular matrix proteins from embryonic mesenchyme have a normalizing effect on cancer cells in vitro and slow tumor growth in vivo. This concept is suggestive of a new method for controlling the growth and spread of existing cancer cells in situ and indicates the possibility that extracellular proteins and/or embryonic mesenchymal fibroblasts may represent a fertile subject for study of new anti-cancer treatments.
摘要
胚胎间充质细胞的细胞外基质蛋白对体外癌细胞具有正常化作用，并能减缓体内肿瘤的生长。这一概念提示了一种新的方法，可用于控制原位现有癌细胞的生长和扩散，并表明细胞外蛋白和/或胚胎间充质成纤维细胞可能成为研究新抗癌治疗方法的一个有前途的课题。
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