Ferlito S, Ricceri M, Ossino A M
Chair of Clinical Systematic Methodology, University of Catania, Ospedale Garibaldi, U.S.L. No. 34.
Int Angiol. 1989 Jul-Sep;8(3):140-4.
The Authors investigated the lipidometabolic effects of calcium heparin in order to assess if the antiatherogenic usefulness of the drug, recently demonstrated in the treatment of thrombosis and myocardial reinfarction, may be linked to its hypolipemiant property in addition to the antithrombotic one. The series consists of 25 normal-weight subjects (9 m, 16 f, mean age 68 +/- 5, RBW 107 +/- 3) of whom 11 were normolipemics (group A) and 14 hyperlipemics (group B) suffering from hyperlipoproteinemia of type IIA (4 cases), IIB (6 cases) and IV (4 cases). After an overnight fasting each subject was given calcium heparin (12,500 Units in a single dose subcutaneously); before and after 20', 1 hr, 2 hr and 6 hr venous blood samples were taken; for each sample plasma levels of triglyceride, total LDL-, total HDL-, HDL-3-, HDL-2-cholesterol, apoprotein CII, and apoprotein CIII were determined. In group A and B, triglycerides showed a significant reduction and total cholesterol a slight one, the "minima" being at the 1st hour after the heparinoid stimulus; the triglyceride reduction was more evident (8%) in group A than in group B (17%). In group A, total HDL-, HDL-2- and HDL-3-cholesterol decreased significantly (P less than 0.01) with a "nadir" at the 2nd hr in group B; total HDL-cholesterol did not change, whereas HDL-3-cholesterol decreased (P less than 0.05) and HDL-2 cholesterol increased (P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
作者研究了钙肝素的脂质代谢作用，以评估该药物最近在血栓形成和心肌再梗死治疗中所显示的抗动脉粥样硬化作用，除抗血栓特性外，是否还与其降血脂特性有关。该研究系列包括25名体重正常的受试者（9名男性，16名女性，平均年龄68±5岁，相对体重107±3），其中11名血脂正常者（A组）和14名高脂血症患者（B组），分别患有IIA型（4例）、IIB型（6例）和IV型（4例）高脂蛋白血症。在禁食过夜后，给每位受试者皮下注射单剂量的钙肝素（12,500单位）；在注射后20分钟、1小时、2小时和6小时采集静脉血样；测定每个样本中甘油三酯、总低密度脂蛋白、总高密度脂蛋白、HDL-3、HDL-2胆固醇、载脂蛋白CII和载脂蛋白CIII的血浆水平。在A组和B组中，甘油三酯显著降低，总胆固醇略有降低，最低值出现在肝素刺激后的第1小时；A组甘油三酯的降低（8%）比B组（17%）更明显。在A组中，总HDL、HDL-2和HDL-3胆固醇显著降低（P<0.01），在B组中第2小时达到最低点；总HDL胆固醇没有变化，而HDL-3胆固醇降低（P<0.05），HDL-2胆固醇升高（P<0.01）。（摘要截选至250字）
