Murphy Mark P, Caraher Emma
Centre for Microbial-Host Interactions, Institute of Technology Tallaght, Old Blessington Road, Tallaght, Dublin 24, Ireland,
Immunol Res. 2015 Jun;62(2):225-33. doi: 10.1007/s12026-015-8655-z.
Upon entry to the systemic circulation, neutrophils exhibit a short mean time to cell death. The viability of most cell types in a steady state is preserved by the interplay of the Bcl-2 family of proteins, wherein the anti-apoptotic members inhibit the action of their pro-apoptotic counterparts. Neutrophils, however, display absent or severely reduced expression of several anti-apoptotic Bcl-2 family proteins. Hence, they rely on the expression of Mcl-1, an anti-apoptotic member of the Bcl-2 family, for survival. This protein is uniquely short-lived relative to related proteins and its loss likely precipitates the induction of apoptosis in neutrophils. This review describes the role of Mcl-1 in the neutrophil in the context of apoptosis and highlights the proteins' importance to the cell. We also address neutrophil apoptosis in the broader context of the cells' response to pathogens, focussing particularly on the strategies used by pathogens to manipulate the apoptotic pathway to their own ends.
进入体循环后，中性粒细胞的平均细胞死亡时间较短。在稳态下，大多数细胞类型的活力通过Bcl-2蛋白家族的相互作用得以维持，其中抗凋亡成员抑制其促凋亡对应物的作用。然而，中性粒细胞表现出几种抗凋亡Bcl-2家族蛋白的表达缺失或严重减少。因此，它们依靠Bcl-2家族的抗凋亡成员Mcl-1的表达来存活。相对于相关蛋白，这种蛋白的寿命特别短，其缺失可能促使中性粒细胞发生凋亡。本综述描述了Mcl-1在中性粒细胞凋亡过程中的作用，并强调了该蛋白对细胞的重要性。我们还在细胞对病原体反应的更广泛背景下探讨中性粒细胞凋亡，特别关注病原体为达到自身目的而操纵凋亡途径所采用的策略。
