Gregori Maria, Masserini Massimo, Mancini Simona
Department of Health Sciences, University of Milano-Bicocca, via Cadore 48, 20900 Monza, Italy.
Nanomedicine (Lond). 2015;10(7):1203-18. doi: 10.2217/nnm.14.206.
Alzheimer's disease affects more than 35 million people worldwide and this number is presumed to double by the year 2050. Currently, there is no efficient therapy for this disorder but a promising approach is represented by nanotechnology, easily multifunctionalizable devices with size in the order of billionth of meter. This review provides a concise survey on the nano-based strategies for Alzheimer's disease treatment, aiming at carrying drugs across the blood-brain barrier, in particular to target the metabolism of β-amyloid peptide, a pivotal player in this pathology.
阿尔茨海默病影响着全球超过3500万人，据推测，到2050年这个数字将翻倍。目前，针对这种疾病尚无有效的治疗方法，但纳米技术提供了一种有前景的方法，纳米技术可以轻松制造出尺寸在十亿分之一米量级的多功能设备。本文综述了基于纳米技术治疗阿尔茨海默病的策略，旨在使药物穿越血脑屏障，特别是针对β-淀粉样肽的代谢，β-淀粉样肽是这种病理过程中的关键因素。
