赋予多药耐药性的小鼠ATP结合盒（ABC）转运蛋白
Mouse ATP-Binding Cassette (ABC) Transporters Conferring Multi-Drug Resistance.
作者信息
Shuaizhang L I, Zhang Wen, Yin Xuejiao, Xing Shilai, Xie Qunhui, Cao Zhengyu, Zhao Bin
机构信息
State Key Laboratory of Natural Medicines and Jiangsu Provincial Key laboratory for TCM Evaluation and Translational Development, China Pharmaceutical University, Nanjing, P.R. China, 211198.
Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
出版信息
Anticancer Agents Med Chem. 2015 Apr 28;15(4):423 - 432.
The ABC (ATP-binding cassette) transporter is one of the largest and most ancient protein families with members functioning from protozoa to human. The resistance of cancer and tumor cells to anticancer drugs is due to the over-expression of some ABC transporters, which may finally lead to chemotherapy failure. The mouse ABC transporters are classified into seven subfamilies by phylogenetic analysis. The mouse ABC transporter gene, alias, chromosomal location and function have been determined. Within the ABC super-family, the MDR transporters (Abcb1, Abcc1, Abcg2) in mouse models have been proved to be valuable to investigate the biochemistry and physiological functions. This review concentrates on the multidrug resistance of mouse ABC transporters in cancer and tumor cells.
ABC（ATP结合盒）转运蛋白是最大且最古老的蛋白质家族之一，其成员在从原生动物到人类的生物中发挥作用。癌症和肿瘤细胞对抗癌药物的耐药性归因于某些ABC转运蛋白的过度表达，这最终可能导致化疗失败。通过系统发育分析，小鼠ABC转运蛋白被分为七个亚家族。小鼠ABC转运蛋白基因、别名、染色体定位及功能已被确定。在ABC超家族中，小鼠模型中的多药耐药转运蛋白（Abcb1、Abcc1、Abcg2）已被证明对研究生物化学和生理功能具有重要价值。本综述聚焦于小鼠ABC转运蛋白在癌症和肿瘤细胞中的多药耐药性。
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