印度泰米尔纳德邦婴儿HIV感染早期诊断面临的挑战
Challenges in the Early Diagnosis of HIV Infection in Infants: Experience from Tamil Nadu, India.
作者信息
Hanna Luke Elizabeth, Siromany Valan Adimai, Annamalai Madheswaran, Karunaianantham Ramesh, Swaminathan Soumya
机构信息
HIV/AIDS Laboratory, Department of Clinical Research, National Institute for Research in Tuberculosis, Chetput; and *Tamil Nadu State AIDS Control Society, Egmore, Chennai, India. Correspondence to: Dr Soumya Swaminathan, Scientist G and Director, National Institute for Research in Tuberculosis, Chetput, Chennai 600 031, India.
出版信息
Indian Pediatr. 2015 Apr;52(4):307-9. doi: 10.1007/s13312-015-0629-7.
OBJECTIVE
To analyze critical steps in the testing algorithm of the National Early Infant Diagnosis (EID) program in India.
METHODS
A retrospective analysis of data on cases enrolled in the EID program during 2010-2012 from Tamil Nadu was undertaken.
RESULTS
2745 dried blood spots were tested; 9% of these tested positive. Median age of infants at the time of testing was 4 months. Second specimen for confirmation was received from 67% of cases with a turn-around time of 10-270 days.
CONCLUSIONS
Even with high levels of uptake into the program, huge delays and loss-to-follow-up observed between the first and second sampling, suggests need for revision of the current testing algorithm.
目的
分析印度国家早期婴儿诊断（EID）项目检测算法中的关键步骤。
方法
对2010 - 2012年期间泰米尔纳德邦参加EID项目的病例数据进行回顾性分析。
结果
检测了2745份干血斑样本；其中9%检测呈阳性。检测时婴儿的中位年龄为4个月。67%的病例收到了用于确认的第二份样本，周转时间为10 - 270天。
结论
即使该项目的参与率很高，但在第一次和第二次采样之间仍观察到巨大延迟和失访情况，这表明需要修订当前的检测算法。
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