帕金森病认知障碍的患病率及危险因素：台湾一项基于人群的病例对照研究
Prevalence and risk factors of cognitive impairment in Parkinson disease: a population-based case-control study in Taiwan.
作者信息
Huang Yu-Ching, Wu Shwu-Tzy, Lin Juei-Jueng, Lin Che-Chen, Kao Chia-Hung
机构信息
From the Department of Neurology (Y-CH), Taoyuan General Hospital, Ministry of Health and Welfare, Executive Yuan; Department of Bioindustry Technology (Y-CH, S-TW), Dayeh University, Chang Hua; Department of Neurology (J-JL), Chushang Show-Chwan Hospital, Nantou; Department of Neurology (J-JL), Chung-Shan Medical University Hospital; Management Office for Health Data (C-CL), China Medical University Hospital; College of Medicine (C-CL); Graduate Institute of Clinical Medical Science (C-HK), China Medical University; and Department of Nuclear Medicine and PET Center (C-HK), China Medical University Hospital, Taichung, Taiwan.
出版信息
Medicine (Baltimore). 2015 May;94(17):e782. doi: 10.1097/MD.0000000000000782.
The aim of this study was to evaluate the Parkinson disease (PD) prevalence of cognitive impairment in Taiwan.The case-control study consisted of 6177 cognitive impairment patients and 24,708 noncognitive impairment as controls for the period of 2006 to 2010 and both of the groups aged ≥50 years. The multivariable logistic regression analyses were used to estimate the odds ratio (OR) for cognitive impairment, and the 95% confidence intervals (CIs) among patients with PD were compared with those of non-PD patients.PD (adjusted odds ratio [aOR] is 3.07, 95% CI 2.76-3.41) is the one of the most contributed risk factors for cognitive impairment. Besides, we found a remarkable result of the diagnosed cognitive impairment of PD that was found highest in the first 6 months (aOR 11.98, 95% CI 8.51-16.86) and then decrease the incident year by year. The PD prevalence in a patient with cognitive impairment in our data present is 12.1% lower than those with truly dementia published previously and documented by western studies.We found a remarkable result of the diagnosed cognitive impairment of PD that was found highest in the first 6 months and then decrease the incident year by year.
本研究旨在评估台湾地区帕金森病（PD）患者认知障碍的患病率。这项病例对照研究涵盖了2006年至2010年期间的6177名认知障碍患者和24708名无认知障碍者作为对照，两组患者年龄均≥50岁。采用多变量逻辑回归分析来估计认知障碍的比值比（OR），并将PD患者与非PD患者的95%置信区间（CIs）进行比较。PD（调整后的比值比[aOR]为3.07，95% CI为2.76 - 3.41）是认知障碍最主要的危险因素之一。此外，我们发现PD患者被诊断为认知障碍的一个显著结果是，在前6个月中发病率最高（aOR为11.98，95% CI为8.51 - 16.86），随后逐年下降。在我们的数据中，患有认知障碍的患者中PD的患病率比先前西方研究记录的真正痴呆患者低12.1%。我们发现PD患者被诊断为认知障碍的一个显著结果是，在前6个月中发病率最高，随后逐年下降。
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