Wu Sheng-Jie, Zhu Gui-Qi, Ye Bo-Zhi, Kong Fan-Qi, Zheng Zai-Xing, Zou Hai, Shi Ke-Qing, Lin Lu, Braddock Martin, Huang Wei-Jian, Chen Yong-Ping, Zheng Ming-Hua
From the Department of Cardiovascular Medicine, the Heart Center (S-JW, B-ZY, F-QK, Z-XZ, LL, W-JH); Department of Infection and Liver Diseases, Liver Research Center, the First Affiliated Hospital of Wenzhou Medical University (G-QZ, K-QS, Y-PC, M-HZ); School of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou (G-QZ); Department of Internal Medicine, Xinyu People's Hospital of Jiangxi Province, Xinyu (HZ); Institute of Hepatology, Wenzhou Medical University, Wenzhou, China (K-QS, Y-PC, M-HZ); and Global Medicines Development, AstraZeneca R&D, Loughborough, United Kingdom (MB).
Medicine (Baltimore). 2015 May;94(17):e802. doi: 10.1097/MD.0000000000000802.
The aim of this study was to examine the association between sex-specific serum uric acid (sUA) levels and NAFLD in a large population-based study.A total of 60,455 subjects from 2 separate medical centers were included. Sex-specific sUA quartiles (Q1-Q4) were defined: ≤330, 331-380, 381-435, and ≥436 μmol/L for male; ≤230, 231-270, 271-310, and ≥311 μmol/L for female. The odds ratios (ORs), hazard ratios (HRs), and 95% confidence intervals (CIs) for NAFLD were calculated across each quartile of sUA, using the Q1 as reference.After adjusting for known confounding variables in this study, the ORs for NAFLD in the cross-sectional population were 1.211 (95% CI 1.109-1.322), 1.519 (95% CI 1.395-1.654), 1.903 (95% CI 1.748-2.072) for Q2, Q3, and Q4, respectively. In the longitudinal population, compared with the reference group, those in Q2, Q3, and Q4 had HRs of 1.127 (95% CI 0.956-1.330), 1.380 (95% CI 1.157-1.644), 1.589 (95% CI 1.310-1.927) for NAFLD, respectively. Analysis for the sex-specific subgroup showed the adjusted ORs for Q4 versus Q1 were 2.898 (95% CI 2.36-3.588) in female and 1.887 (95% CI 1.718-2.072) in male in the cross-sectional population. In the longitudinal population, the HRs for the Q4 were 2.355 (95% CI 1.702-3.259) in female and 1.249 (95% CI 0.975-1.601) in male, compared with Q1.We report that a sex-specific sUA level is independently associated with NAFLD. The association between sUA and NAFLD was significantly greater in females than in males.
本研究的目的是在一项基于大规模人群的研究中，探讨性别特异性血清尿酸（sUA）水平与非酒精性脂肪性肝病（NAFLD）之间的关联。纳入了来自2个不同医疗中心的总共60455名受试者。定义了性别特异性的sUA四分位数（Q1-Q4）：男性为≤330、331-380、381-435和≥436μmol/L；女性为≤230、231-270、271-310和≥311μmol/L。以Q1为参照，计算各sUA四分位数组中NAFLD的比值比（OR）、风险比（HR）和95%置信区间（CI）。在对本研究中已知的混杂变量进行校正后，横断面人群中NAFLD的OR值在Q2、Q3和Q4组分别为1.211（95%CI 1.109-1.322）、1.519（95%CI 1.395-1.654）、1.903（95%CI 1.748-2.072）。在纵向人群中，与参照组相比，Q2、Q3和Q4组中NAFLD的HR值分别为1.127（95%CI 0.956-1.330）、1.380（95%CI 1.157-1.644）、1.589（95%CI 1.310-1.927）。对性别特异性亚组的分析显示，在横断面人群中，女性Q4组与Q1组相比校正后的OR值为2.898（95%CI 2.36-3.588），男性为1.887（95%CI 1.718-2.072）。在纵向人群中，与Q1组相比，女性Q4组的HR值为2.355（95%CI 1.702-3.259），男性为1.249（95%CI 0.975-1.601）。我们报告性别特异性sUA水平与NAFLD独立相关。sUA与NAFLD之间的关联在女性中显著大于男性。
