从重氮盐合成放射性标记芳基叠氮化物：实验和计算结果允许确定首选机制。
Synthesis of radiolabelled aryl azides from diazonium salts: experimental and computational results permit the identification of the preferred mechanism.
机构信息
Radiochemistry and Nuclear Imaging, CIC biomaGUNE, Paseo Miramón 182, Parque Tecnológico de San Sebastián, 20009, San Sebastián/Donostia, Spain.
出版信息
Chem Commun (Camb). 2015 May 28;51(43):8954-7. doi: 10.1039/c5cc01913c.
PMID:25929958
Abstract
Experimental and computational studies on the formation of aryl azides from the corresponding diazonium salts support a stepwise mechanism via acyclic zwitterionic intermediates. The low energy barriers associated with both transition structures are compatible with very fast and efficient processes, thus making this method suitable for the chemical synthesis of radiolabelled aryl azides.
摘要
实验和计算研究表明，芳基重氮盐形成芳基叠氮化物的反应是通过非循环两性离子中间体的分步机制进行的。两个过渡态都具有较低的能垒，这与非常快速和高效的过程是一致的，因此这种方法适用于放射性标记芳基叠氮化物的化学合成。
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