Vieira D N, de Azevedo-Bernarda R
J Toxicol Clin Exp. 1989 May-Jun;9(3):177-86.
The preliminary results of a study of the pulmonary histopathological injuries observed in autopsy samples from six paraquat poisoning cases are presented. The pattern of the pulmonary injuries is discussed with regard to the survival time. Twenty-four hours after the ingestion, intense edema of the alveolar walls, congestion, capillary thrombosis and infiltrations of polynuclears in the septa were observed. Areas of ischemic necrosis were also noticed. Four days after the ingestion the histological changes remained. Six days after it was already observed the formation of hyaline membranes. After nine days the histological patterns changed, with thickness and septal fibrosis and residues of hyaline membranes.
本文呈现了对6例百草枯中毒病例尸检样本中观察到的肺部组织病理学损伤的初步研究结果。针对生存时间探讨了肺部损伤的模式。摄入后24小时，观察到肺泡壁严重水肿、充血、毛细血管血栓形成以及隔内多核细胞浸润。还注意到缺血性坏死区域。摄入后4天，组织学变化依然存在。摄入后6天，已观察到透明膜形成。9天后，组织学模式发生改变，出现间隔增厚和纤维化以及透明膜残留。
