Rebello G, Mason J K
Histopathology. 1978 Jan;2(1):53-66. doi: 10.1111/j.1365-2559.1978.tb01693.x.
The paper describes the histological appearances in the lungs from 11 fatal cases of paraquat poisoning. The study originated as an attempt to define the sequential changes in the condition and, from them, to assess the mode of action of the herbicide in the human. The main features of the "paraquat lung" include haemorrhage, extrusion of macrophages, oedema, "honeycombing", fibrosis and, rarely, epithelial hyperplasia. The indications are that the changes are progressive once a threshold tissue concentration has been reached. The appearances are compared to those in poisoning by hyperbaric oxygen and it is hypothesized that the toxic action of paraquat is to sensitize the lungs to oxygen at atmospheric pressure.
本文描述了11例百草枯中毒致死病例肺部的组织学表现。该研究源于试图明确病情的连续变化，并据此评估除草剂在人体中的作用方式。“百草枯肺”的主要特征包括出血、巨噬细胞渗出、水肿、“蜂窝状改变”、纤维化，以及罕见的上皮增生。有迹象表明，一旦达到阈值组织浓度，这些变化就会进展。将这些表现与高压氧中毒的表现进行了比较，并推测百草枯的毒性作用是使肺部对常压下的氧气敏感。
