Okamura Koichi, Kobayashi Tsutomu, Yamamoto Atsushi, Shitara Hitoshi, Osawa Toshihisa, Ichinose Tsuyoshi, Takagishi Kenji
Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.
Department of Physical Therapy, Takasaki University of Health and Welfare, Takasaki, Gunma, Japan.
Int J Rheum Dis. 2017 Feb;20(2):177-181. doi: 10.1111/1756-185X.12581. Epub 2015 Apr 30.
Rotator cuff disease (RCD) is one of the most common disorders in the shoulder joint and causes joint pain and functional disability. In this study, we investigated the associations among cytokine levels and clinical symptoms in patients with RCD.
Joint fluid specimens of the shoulder joint were obtained from 38 patients with RCD before arthroscopic surgery. The levels of inflammatory cytokines, including interleukin (IL)-1β, IL-6 and IL-8, were evaluated using enzyme-linked immunosorbent assay kits, and the associations between these cytokine levels and the clinical symptoms were determined. A multiple linear regression analysis was performed to identify the parameters accounting for the visual analogue scale (VAS) score at rest.
IL-8 level was correlated with IL-6 (r = 0.434, P = 0.006) and IL-1β (r = 0.575, P < 0.001) levels. The cuff tear size was inversely correlated with the VAS score at rest. A multiple stepwise linear regression analysis revealed that the VAS score at rest could be explained by the VAS score at night, the VAS score during movement and the intra-articular IL-8 level (adjusted R² = 0.544, P < 0.001). The intra-articular IL-8 level is associated with resting pain in rotator cuff tear patients.
These results suggest that an increased concentration of IL-8 is associated with resting pain in rotator cuff tear patients.
肩袖疾病（RCD）是肩关节最常见的疾病之一，可导致关节疼痛和功能障碍。在本研究中，我们调查了RCD患者细胞因子水平与临床症状之间的关联。
在关节镜手术前，从38例RCD患者获取肩关节的关节液标本。使用酶联免疫吸附测定试剂盒评估包括白细胞介素（IL）-1β、IL-6和IL-8在内的炎性细胞因子水平，并确定这些细胞因子水平与临床症状之间的关联。进行多元线性回归分析以确定影响静息视觉模拟评分（VAS）的参数。
IL-8水平与IL-6（r = 0.434，P = 0.006）和IL-1β（r = 0.575，P < 0.001）水平相关。肩袖撕裂大小与静息VAS评分呈负相关。多元逐步线性回归分析显示，静息VAS评分可由夜间VAS评分、运动时VAS评分和关节内IL-8水平解释（调整R² = 0.544，P < 0.001）。关节内IL-8水平与肩袖撕裂患者的静息疼痛相关。
这些结果表明，IL-8浓度升高与肩袖撕裂患者的静息疼痛相关。
