Özçınar Beyza, Aksakal Nihat, Yanar Fatih, Ağcaoğlu Orhan, Peker Kıvanç Derya, Türkoğlu Ümit, Mercan Selçuk, Özarmağan Selçuk, Erbil Yeşim
Department of General Surgery, İstanbul University İstanbul Faculty of Medicine, İstanbul, Turkey.
Department of Biochemistry, İstanbul University, İstanbul Faculty of Medicine, İstanbul, Turkey.
Ulus Cerrahi Derg. 2014 Jun 1;30(2):80-4. doi: 10.5152/UCD.2014.2484. eCollection 2014.
The aim of this study was to consider levels of the proinflammatory cytokines IL-1 and TNFα after thyroid surgery.
A total of 200 patients who underwent total thyroidectomy enrolled in this study. Drain fluid samples were taken. IL-1 and TNFα results and their relationship with other factors were analyzed.
There was a positive correlation between IL-1 and hyperthyroidism (rs=0.614, p<0.001), operative time (rs=0.770, p<0.001), and excised thyroid volume (rs=0.829, p<0.001). Moreover, there was a positive correlation between TNFα and hyperthyroidism (rs=0.430, p<0.001), operative time (rs=0.392, p<0.001), and excised thyroid volume (rs=0.398, p<0.001).
The results of this study showed us that the parameters related to increased proinflammatory cytokine levels after thyroid surgery were hyperthyroidism, operative time, and excised thyroid volume, but this increase did not show us any clinical outcomes related to these parameters.
本研究旨在探讨甲状腺手术后促炎细胞因子白细胞介素-1（IL-1）和肿瘤坏死因子α（TNFα）的水平。
本研究共纳入200例行甲状腺全切除术的患者。采集引流液样本。分析IL-1和TNFα的结果及其与其他因素的关系。
IL-1与甲状腺功能亢进（rs=0.614，p<0.001）、手术时间（rs=0.770，p<0.001）及切除甲状腺体积（rs=0.829，p<0.001）呈正相关。此外，TNFα与甲状腺功能亢进（rs=0.430，p<0.001）、手术时间（rs=0.392，p<0.001）及切除甲状腺体积（rs=0.398，p<0.001）呈正相关。
本研究结果表明，甲状腺手术后促炎细胞因子水平升高相关的参数为甲状腺功能亢进、手术时间及切除甲状腺体积，但这种升高并未显示出与这些参数相关的任何临床结果。
