防晒霜使用与恶性黑色素瘤风险之间的关联分析。
Analysis of association between sunscreens use and risk of malignant melanoma.
作者信息
Xie Fang, Xie Tingting, Song Qi, Xia Shan, Li Hengjin
机构信息
Department of Dermatology, Chinese PLA General Hospital Beijing 100853 ; Medical College of PLA Beijing 100853, P. R. China.
Department of Pharmaceutical Care, Chinese PLA General Hospital Beijing 100853.
出版信息
Int J Clin Exp Med. 2015 Feb 15;8(2):2378-84. eCollection 2015.
BACKGROUND
Epidemiological studies evaluating the association between sunscreens use and malignant melanoma risk have produced inconsistent results. Thus, we conducted a meta-analysis to summarize the evidence from epidemiological studies of sunscreens use with the risk of malignant melanoma.
METHODS
Pertinent studies were identified by a search in PubMed and Web of Knowledge up to October 2014. Random-effect model was used to combine the results. Publication bias was estimated using Egger's regression asymmetry test.
RESULTS
Twenty-one studies including 7150 malignant melanoma cases about sunscreens use with the risk of malignant melanoma were included in this meta-analysis. The combined relative risk (RR) of malignant melanoma associated with sunscreens use was 1.145 (95% CI=0.912-1.438). The association was significant neither in the case-control studies nor in the cohort studies. No publication biases were found.
CONCLUSIONS
Our analysis indicated that sunscreens use is not associated with the risk of malignant melanoma.
背景
评估防晒霜使用与恶性黑色素瘤风险之间关联的流行病学研究结果并不一致。因此，我们进行了一项荟萃分析，以总结来自防晒霜使用与恶性黑色素瘤风险的流行病学研究证据。
方法
通过检索截至2014年10月的PubMed和Web of Knowledge来确定相关研究。采用随机效应模型合并结果。使用Egger回归不对称检验估计发表偏倚。
结果
本荟萃分析纳入了21项研究，包括7150例关于防晒霜使用与恶性黑色素瘤风险的恶性黑色素瘤病例。与防晒霜使用相关的恶性黑色素瘤合并相对风险（RR）为1.145（95%CI = 0.912 - 1.438）。该关联在病例对照研究和队列研究中均不显著。未发现发表偏倚。
结论
我们的分析表明，使用防晒霜与恶性黑色素瘤风险无关。
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