加工肉类和红肉消费与胶质瘤风险之间的关联：来自14篇文章的荟萃分析

Association between processed meat and red meat consumption and risk for glioma: a meta-analysis from 14 articles.

作者信息

Wei Youdong, Zou Dezhi, Cao Du, Xie Peng

机构信息

Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Institute of Neuroscience, Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Neurobiology, Chongqing, China.

Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Neurobiology, Chongqing, China.

出版信息

Nutrition. 2015 Jan;31(1):45-50. doi: 10.1016/j.nut.2014.04.022. Epub 2014 May 10.

DOI:10.1016/j.nut.2014.04.022

PMID:25466652

Abstract

OBJECTIVE

Epidemiologic studies evaluating the association between processed meat and red meat consumption and glioma risk have produced inconsistent results. Thus, the aim of this study was to conduct a meta-analysis to test the hypothesis that high levels of processed meat consumption could increase the risk for glioma.

METHODS

Pertinent studies were identified by a search of PubMed and Web of Knowledge up to February 2014. Random-effects model was used to combine the results. Publication bias was estimated using Egger's regression asymmetry test.

RESULTS

Fourteen studies involving 3641 cases about processed meat consumption and 3 studies involving 1156 cases about red meat consumption with risk for glioma were included in this meta-analysis. The combined relative risk (RR) of glioma associated with processed meat consumption was 1.25 (95% confidence interval [CI], 1.08-1.45) overall, and 1.28 (95% CI, 1.09-1.50) in the United States. For subgroup of study design, significant association was also found in case-control studies (RR, 1.33; 95% CI, 1.09-1.62), but not in the cohort studies. The association was not significant between red meat consumption and glioma risk (summary RR, 0.89; 95% CI, 0.71-1.12). No publication biases were found.

CONCLUSIONS

Our analysis indicated that high levels of processed meat consumption might increase the risk for glioma, and findings are consistent with the hypothesis. No association was found between red meat consumption and glioma risk.

摘要

目的

评估加工肉类和红肉消费与胶质瘤风险之间关联的流行病学研究结果并不一致。因此，本研究的目的是进行一项荟萃分析，以检验高加工肉类消费量会增加患胶质瘤风险这一假设。

方法

通过检索截至2014年2月的PubMed和Web of Knowledge确定相关研究。采用随机效应模型合并结果。使用Egger回归不对称检验估计发表偏倚。

结果

本荟萃分析纳入了14项涉及3641例加工肉类消费与胶质瘤风险的研究以及3项涉及1156例红肉消费与胶质瘤风险的研究。总体而言，与加工肉类消费相关的胶质瘤合并相对风险（RR）为1.25（95%置信区间[CI]，1.08 - 1.45），在美国为1.28（95%CI，1.09 - 1.50）。对于研究设计亚组，在病例对照研究中也发现了显著关联（RR，1.33；95%CI，1.09 - 1.62），但队列研究中未发现。红肉消费与胶质瘤风险之间的关联不显著（汇总RR，0.89；95%CI，0.71 - 1.12）。未发现发表偏倚。