帕金森病患者丘脑底核和脚桥核的深部脑刺激
Deep brain stimulation of the subthalamic and pedunculopontine nucleus in a patient with Parkinson's disease.
作者信息
Liu Huan-Guang, Zhang Kai, Yang An-Chao, Zhang Jian-Guo
机构信息
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. ; Department of Stereotactic and Functional Neurosurgery, Beijing Neurosurgical Institute, Beijing, China.
出版信息
J Korean Neurosurg Soc. 2015 Apr;57(4):303-6. doi: 10.3340/jkns.2015.57.4.303. Epub 2015 Apr 24.
Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel therapy developed to treat Parkinson's disease. We report a patient who underwent bilateral DBS of the PPN and subthalamic nucleus (STN). He suffered from freezing of gait (FOG), bradykinesia, rigidity and mild tremors. The patient underwent bilateral DBS of the PPN and STN. We compared the benefits of PPN-DBS and STN-DBS using motor and gait subscores. The PPN-DBS provided modest improvements in the gait disorder and freezing episodes, while the STN-DBS failed to improve the dominant problems. This special case suggests that PPN-DBS may have a unique role in ameliorating the locomotor symptoms and has the potential to provide improvement in FOG.
对脚桥核（PPN）进行深部脑刺激（DBS）是一种为治疗帕金森病而开发的新型疗法。我们报告了一名接受双侧PPN和丘脑底核（STN）DBS治疗的患者。他患有步态冻结（FOG）、运动迟缓、僵硬和轻度震颤。该患者接受了双侧PPN和STN的DBS治疗。我们使用运动和步态子评分比较了PPN-DBS和STN-DBS的疗效。PPN-DBS在步态障碍和冻结发作方面有适度改善，而STN-DBS未能改善主要问题。这个特殊病例表明，PPN-DBS在改善运动症状方面可能具有独特作用，并且有可能改善步态冻结。
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