Itoyama T, Sadamori N, Tokunaga S, Sasagawa I, Nakamura H, Yao E, Jubashi T, Yamada Y, Ikeda S, Ichimaru M
Rinsho Ketsueki. 1989 Oct;30(10):1769-77.
The chromosome 14q11 anomaly has been reported to be specific to adult T-cell leukemia (ATL) and this anomaly has also been confirmed in preleukemic state of ATL (pre-ATL) patients though the frequency is low. In an attempt to clarify if the same chromosome aberrations could be found also at the stage of HTLV-I carrier and if there is any cytogenetic difference from non-HTLV-I carriers, a cytogenetic study of lymphocytes stimulated with phytohemagglutinin in three HTLV-I healthy carriers and three non-HTLV-I carriers in an ATL family was performed. The results were as follows. 1. In three HTLV-I carriers, 7 of 311 cells examined (2.3%) showed chromosome aberrations, and 4 cells (1.3%) had 14q11 anomaly. 2. In three non-HTLV-I carriers, 4 of 260 cells examined (1.5%) showed chromosome aberrations, whereas no cells had 14q11 anomaly. These findings suggest that 14q11 anomaly is already present at the stage of HTLV-I carrier and seems to be an important cytogenetic clue to the pathogenesis of ATL.
据报道，14号染色体q11异常是成人T细胞白血病（ATL）所特有的，并且在ATL的白血病前期状态（pre-ATL）患者中也得到了证实，尽管出现频率较低。为了弄清楚在HTLV-I携带者阶段是否也能发现相同的染色体畸变，以及与非HTLV-I携带者是否存在细胞遗传学差异，我们对一个ATL家族中的三名HTLV-I健康携带者和三名非HTLV-I携带者的淋巴细胞进行了植物血凝素刺激后的细胞遗传学研究。结果如下：1. 在三名HTLV-I携带者中，311个检测细胞中有7个（2.3%）显示出染色体畸变，4个细胞（1.3%）存在14q11异常。2. 在三名非HTLV-I携带者中，260个检测细胞中有4个（1.5%）显示出染色体畸变，但没有细胞存在14q11异常。这些发现表明，14q11异常在HTLV-I携带者阶段就已存在，似乎是ATL发病机制的一个重要细胞遗传学线索。
