Ikeda S, Momita S, Amagasaki T, Tsukasaki K, Yamada Y, Kusumoto Y, Ito M, Kanda N, Tomonaga M, Soda H
Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
Cancer Detect Prev. 1990;14(4):431-5.
The prevalence of the preleukemic state of adult T-cell leukemia (pre-ATL) was studied in Nagasaki prefecture, one of the endemic human T-lymphotropic virus type 1 (HTLV-1) areas in Japan. Pre-ATL cases have the monoclonal proliferation of abnormal lymphocytes, without signs of malignant proliferation or clinical signs and symptoms related to leukemia. HTLV-1 carriers who have monoclonal integration of HTLV-1 proviral DNA may be at high risk of developing ATL. Abnormal lymphocytes with either bilobular or large and chromatin-rich nuclei were found in 63/356 (17.7%) of HTLV-1 carriers among inhabitants. We analyzed DNA of peripheral lymphocytes from 108 carries with abnormal lymphocytes by Southern blot technique. Monoclonal integration of HTLV-1 has been detected in 12 cases (11.1%). These results lead to the conclusion that the prevalence rate of pre-ATL among all HTLV-1 carriers is about 2%. Pre-ATL is presumed to be the clinical stage which precedes ATL, although the possibility remains that the HTLV-1 carrier may develop symptoms of ATL directly, without going through the pre-ATL stage.
在日本长崎县(日本1型人类嗜T淋巴细胞病毒(HTLV-1)流行地区之一),对成人T细胞白血病前期状态(pre-ATL)的患病率进行了研究。Pre-ATL病例存在异常淋巴细胞的单克隆增殖,但无恶性增殖迹象或与白血病相关的临床体征和症状。HTLV-1前病毒DNA发生单克隆整合的HTLV-1携带者可能有患成人T细胞白血病(ATL)的高风险。在居民中的HTLV-1携带者中,63/356(17.7%)发现了具有双叶核或大且富含染色质核的异常淋巴细胞。我们通过Southern印迹技术分析了108例有异常淋巴细胞携带者的外周淋巴细胞DNA。在12例(11.1%)中检测到HTLV-1的单克隆整合。这些结果得出结论,所有HTLV-1携带者中pre-ATL的患病率约为2%。尽管HTLV-1携带者仍有可能不经过pre-ATL阶段而直接出现ATL症状,但pre-ATL被认为是ATL之前的临床阶段。