人类I型T细胞白血病病毒携带者的细胞遗传学研究。一项家族研究。

Cytogenetic studies of human T-cell leukemia virus type I carriers. A family study.

作者信息

Itoyama T, Sadamori N, Tokunaga S, Sasagawa I, Nakamura H, Yao E, Jubashi T, Yamada Y, Ikeda S, Ichimaru M

机构信息

Department of Hematology, Nagasaki University School of Medicine, Japan.

出版信息

Cancer Genet Cytogenet. 1990 Oct 15;49(2):157-63. doi: 10.1016/0165-4608(90)90137-y.

DOI:10.1016/0165-4608(90)90137-y

PMID:2208053

Abstract

Recently, the chromosome 14q11 anomaly has been reported to be specific to adult T-cell leukemia (ATL), and this anomaly has also been confirmed in the preleukemic state of adult T-cell leukemia (pre-ATL) patients. Because the cytogenetic abnormality at the stage of human T-cell leukemia virus type I (HTLV-I) carrier remains uncertain, we performed cytogenetic studies of lymphocytes stimulated with phytohemagglutinin in three HTLV-I carriers and three non-HTLV-I carriers in an ATL family. As a result, in three HTLV-I carriers, four of 311 cells examined (1.3%) had chromosome 14q11 anomaly. However, in three non-HTLV-I carriers, none of 260 cells examined had chromosome 14q11 anomaly. These results suggest that chromosome 14q11 anomaly is already present at the stage of HTLV-I carrier and seems to be an important cytogenetic clue to the pathogenesis of ATL.

摘要

最近，据报道14号染色体q11异常是成人T细胞白血病（ATL）所特有的，并且在成人T细胞白血病的白血病前期状态（pre-ATL）患者中也证实了这种异常。由于人类T细胞白血病病毒I型（HTLV-I）携带者阶段的细胞遗传学异常仍不确定，我们对一个ATL家族中的三名HTLV-I携带者和三名非HTLV-I携带者进行了用植物血凝素刺激的淋巴细胞的细胞遗传学研究。结果，在三名HTLV-I携带者中，所检测的311个细胞中有4个（1.3%）存在14号染色体q11异常。然而，在三名非HTLV-I携带者中，所检测的260个细胞中没有一个存在14号染色体q11异常。这些结果表明，14号染色体q11异常在HTLV-I携带者阶段就已经存在，似乎是ATL发病机制的一个重要细胞遗传学线索。