甲基转移酶：功能与应用。

Biocatalysis, Department of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629 HZ, Delft (The, Netherlands.

Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.

Chembiochem. 2022 Sep 16;23(18):e202200212. doi: 10.1002/cbic.202200212. Epub 2022 Jul 5.

In this review the current state-of-the-art of S-adenosylmethionine (SAM)-dependent methyltransferases and SAM are evaluated. Their structural classification and diversity is introduced and key mechanistic aspects presented which are then detailed further. Then, catalytic SAM as a target for drugs, and approaches to utilise SAM as a cofactor in synthesis are introduced with different supply and regeneration approaches evaluated. The use of SAM analogues are also described. Finally O-, N-, C- and S-MTs, their synthetic applications and potential for compound diversification is given.

在这篇综述中，评估了 S-腺苷甲硫氨酸 (SAM)-依赖性甲基转移酶和 SAM 的最新技术。介绍了它们的结构分类和多样性，并提出了关键的机制方面，然后进一步详细介绍。然后，介绍了催化 SAM 作为药物靶点，以及利用 SAM 作为合成辅助因子的方法，并评估了不同的供应和再生方法。还描述了 SAM 类似物的使用。最后，介绍了 O-、N-、C-和 S-MTs，及其在合成中的应用和化合物多样化的潜力。