Hewer Ekkehard, Beck Jürgen, Kellner-Weldon Frauke, Vajtai Istvan
Institute of Pathology, University of Bern, 3010 Bern, Switzerland.
Department of Neurosurgery, Inselspital, Bern University Hospital, and University of Bern, 3010 Bern, Switzerland.
Hum Pathol. 2015 Jul;46(7):1045-9. doi: 10.1016/j.humpath.2015.03.005. Epub 2015 Mar 25.
Chordoid glioma of the third ventricle is a rare neuroepithelial tumor characterized by a unique histomorphology and exclusive association with the suprasellar/third ventricular compartment. Variously interpreted as either astrocytic- or ependymal-like, and speculatively ascribed to the lamina terminalis/subcommissural organ, its histogenesis remains, nevertheless, unsettled. Here, we report on a suprasellar chordoid glioma occurring in a 52-year-old man. Although displaying otherwise typical morphological features, the tumor was notable for expression of thyroid transcription factor 1, a marker of tumors of pituicytic origin in the context of the sellar region. We furthermore found overlapping immunoprofiles of this example of chordoid glioma and pituicytic tumors (pituicytoma and spindle cell oncocytoma), respectively. Specifically, phosphorylated ribosomal protein S6, a marker of mTOR pathway activation, was expressed in both groups. Based on these findings, we suggest that chordoid glioma and pituicytic tumors may form part of a spectrum of lineage-related neoplasms of the basal forebrain.
第三脑室脊索样胶质瘤是一种罕见的神经上皮肿瘤，其特征为独特的组织形态学以及仅与鞍上/第三脑室区域相关。它被不同地解释为星形细胞样或室管膜样，并且推测与终板/联合下器官有关，但其组织发生仍未确定。在此，我们报告一例发生于一名52岁男性的鞍上脊索样胶质瘤。尽管该肿瘤表现出其他典型的形态学特征，但它因表达甲状腺转录因子1而引人注目，在鞍区背景下，甲状腺转录因子1是垂体细胞瘤起源肿瘤的标志物。我们还分别发现了该例脊索样胶质瘤与垂体细胞瘤（垂体细胞瘤和梭形细胞嗜酸细胞瘤）的免疫表型重叠。具体而言，mTOR通路激活的标志物磷酸化核糖体蛋白S6在两组中均有表达。基于这些发现，我们认为脊索样胶质瘤和垂体细胞瘤可能构成基底前脑一系列谱系相关肿瘤的一部分。
