乳腺癌中CIRBP mRNA水平与HIF1α基因表达及微血管密度相关。

CIRBP mRNA level in breast cancer is associated with HIF1α gene expression and microvascular density.

作者信息

Monjezi Sajad, Soleimani Vahid, Cheraghzadeh Maryam, Ghanbari Saeed, Adelipour Maryam

机构信息

Department of Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Cellular and molecular research center, Medical Basic Science Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

出版信息

BMC Res Notes. 2025 May 4;18(1):202. doi: 10.1186/s13104-025-07265-5.

DOI:10.1186/s13104-025-07265-5

PMID:40320538

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12049796/

Abstract

OBJECTIVE

Based on the available evidence, the cold-inducible RNA-binding protein (CIRBP) appears to play a role in increasing the stability of hypoxia-inducible factor 1-alpha (HIF1α) mRNA. This research aimed to examine the levels of CIRBP and HIF1α mRNA within breast tumor tissues and explore the relationship between their gene expression and tumor Microvascular density (MVD).

RESULTS

The results revealed a significant upregulation of CIRBP (5.07-fold) and HIF1α (4.5-fold) gene expression in BC samples compared to the surrounding normal tissues (p < 0.001). This upregulation was also associated with various clinicopathologic features. Furthermore, there was a correlation between CIRBP mRNA expression, HIF1α mRNA expression, and MVD. Consequently, this study suggests that CIRBP may have a role in promoting angiogenesis in BC.

摘要

目的

基于现有证据，冷诱导RNA结合蛋白（CIRBP）似乎在增加缺氧诱导因子1α（HIF1α）mRNA稳定性方面发挥作用。本研究旨在检测乳腺肿瘤组织中CIRBP和HIF1α mRNA的水平，并探讨它们的基因表达与肿瘤微血管密度（MVD）之间的关系。

结果

结果显示，与周围正常组织相比，乳腺癌（BC）样本中CIRBP（5.07倍）和HIF1α（4.5倍）基因表达显著上调（p < 0.001）。这种上调还与各种临床病理特征相关。此外，CIRBP mRNA表达、HIF1α mRNA表达与MVD之间存在相关性。因此，本研究表明CIRBP可能在促进乳腺癌血管生成中发挥作用。