Boyle Terry, Gallagher Richard P, Gascoyne Randy D, Connors Joseph M, Le Nhu D, Spinelli John J
Cancer Control Research, British Columbia Cancer Agency, Vancouver, British Columbia, Canada. School of Population and Public Health, The University of British Columbia, Vancouver, British Columbia, Canada. Centre for Medical Research, The University of Western Australia, Perth, Western Australia, Australia.
Cancer Control Research, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
Cancer Epidemiol Biomarkers Prev. 2015 May;24(5):873-7. doi: 10.1158/1055-9965.EPI-14-1303.
Research regarding the association between physical activity and the risk of non-Hodgkin lymphoma (NHL) is limited and inconsistent, and few studies have investigated whether the intensity and timing of physical activity influence the association. A case-control study of NHL was conducted in British Columbia, Canada, in 2000 to 2004. Data were collected on various NHL risk factors, including moderate-intensity and vigorous-intensity physical activity performed over the lifetime. Logistic regression was used to estimate the association between physical activity and the risk of NHL. This analysis included 818 controls and 749 cases. Lifetime vigorous-intensity physical activity was inversely associated with NHL risk. Participants in the second, third, and fourth quartiles of lifetime vigorous-intensity physical activity had an approximately 25% to 30% lower risk of NHL than those in the lowest quartile [adjusted odds ratios, 0.69 (95% confidence interval [CI], 0.52-0.93); 0.68 (95% CI, 0.50-0.92); and 0.75 (95% CI, 0.55-1.01), respectively]. No consistent associations were observed for total or moderate-intensity physical activity. There were no apparent age periods in which physical activity appeared to confer a greater risk reduction. In this study, we found that lifetime vigorous-intensity physical activity was associated with a significantly reduced risk of NHL. Given this finding, more research on physical activity intensity and timing in relation to NHL risk is warranted.
关于身体活动与非霍奇金淋巴瘤（NHL）风险之间关联的研究有限且结果不一致，很少有研究调查身体活动的强度和时间是否会影响这种关联。2000年至2004年在加拿大不列颠哥伦比亚省进行了一项NHL病例对照研究。收集了各种NHL风险因素的数据，包括一生中进行的中等强度和高强度身体活动。采用逻辑回归来估计身体活动与NHL风险之间的关联。该分析纳入了818名对照和749例病例。一生中的高强度身体活动与NHL风险呈负相关。一生中高强度身体活动处于第二、第三和第四四分位数的参与者患NHL的风险比最低四分位数的参与者低约25%至30%[调整后的优势比分别为0.69（95%置信区间[CI]，0.52 - 0.93）；0.68（95%CI，0.50 - 0.92）；和0.75（95%CI，0.55 - 1.01）]。未观察到总身体活动或中等强度身体活动与NHL之间存在一致的关联。没有明显的年龄段显示身体活动能带来更大的风险降低。在本研究中，我们发现一生中的高强度身体活动与NHL风险显著降低相关。鉴于这一发现，有必要对与NHL风险相关的身体活动强度和时间进行更多研究。
