Xu Bo, Ren Li, Tu Weifeng, Wu Zenghui, Ai Fuzhi, Zhou Dongxu, Chen Biyun, Zhang Xingan
Department of Anesthesiology, General Hospital of Guangzhou Military Command, Guangzhou, 510010, China.
Department of Anesthesiology, Zhuhai People's Hospital, Zhuhai, 519000, China.
Eur Spine J. 2017 Mar;26(3):825-831. doi: 10.1007/s00586-015-3979-x. Epub 2015 May 3.
A prospective randomized clinical trial was carried out to observe the analgesic efficacy of ropivacaine for postoperative pain following thoracolumbar spinal surgery.
Seventy-one patients with elective posterior thoracolumbar spinal surgery were randomly divided into two groups. Local group received 0.33 % ropivacaine by pump through the wound, and intravenous group received flurbiprofen axetil, pentazocine and palonosetron via intravenous pump. We evaluated the level of pain, the incidence of adverse reactions at 2, 4, 6, 12, 24, 36 and 48 h after operation, and the occurrence of chronic pain 3 months later.
There were no significant differences in the pain level between the two groups. However, the incidence of nausea, vomiting and chronic pain was significantly lower in the local group.
Our results showed that local infusion of ropivacaine achieved similar analgesic effects to intravenous delivery of analgesic drugs, but significantly reduced incidence of nausea, vomiting and chronic pain.
进行一项前瞻性随机临床试验，以观察罗哌卡因对胸腰椎脊柱手术后疼痛的镇痛效果。
71例行择期胸腰椎后路脊柱手术的患者被随机分为两组。局部组通过伤口泵入0.33%罗哌卡因，静脉组通过静脉泵给予氟比洛芬酯、喷他佐辛和帕洛诺司琼。我们评估了术后2、4、6、12、24、36和48小时的疼痛程度、不良反应发生率，以及3个月后慢性疼痛的发生情况。
两组之间的疼痛程度无显著差异。然而，局部组恶心、呕吐和慢性疼痛的发生率显著较低。
我们的结果表明，局部输注罗哌卡因与静脉注射镇痛药具有相似的镇痛效果，但显著降低了恶心、呕吐和慢性疼痛的发生率。
