Zhang Weiwei, Huang Bo, She Chaokun, Liu Yan, Tong Huabo, Wang Fengxue, Wu Kaifeng
Department of Pediatric Health Care, The Third Affiliated Hospital of Zunyi Medical College, Zunyi, China. E-mail.
Saudi Med J. 2015 May;36(5):593-8. doi: 10.15537/smj.2015.5.10859.
To re-evaluate the epidemiology of hand, foot, and mouth disease (HFMD) in a non-vaccinated population in Zunyi, China.
We used laboratory-based data from the Third Affiliated Hospital of Zunyi Medical College, Zunyi, China to assess the epidemiology of the HFMD caused by enteroviruses between January 2012 and November 2014. Real-time polymerase chain reaction was used to determine human enteroviruses from a total of 12313 probable cases enrolled in this retrospective study. All analyses were stratified by enterovirus serotype, gender, and age.
Virological results were available for 12313 cases of probable HFMD. A total of 5750 cases were positive for viral detection, and the positive rates of infection caused by other enteroviruses was 46.7%, EV71 9%, and CVA16 4.7%. During the study period there was a substantial increase in the occurrence of HFMD. Most of the HFMD patients (87.4%) were aged 0-59 months (median 24; range 0-59). Males showed a higher HFMD prevalence rate (62.4%) than females (37.6%).
Enterovirus infection remains an important public health problem and other entroviruses are emerging as the major causative agent of the HFMD in Zunyi, China.
重新评估中国遵义未接种疫苗人群中手足口病（HFMD）的流行病学特征。
我们利用中国遵义遵义医学院第三附属医院基于实验室的数据，评估2012年1月至2014年11月期间由肠道病毒引起的手足口病的流行病学特征。采用实时聚合酶链反应从这项回顾性研究纳入的总共12313例疑似病例中检测人肠道病毒。所有分析按肠道病毒血清型、性别和年龄分层。
12313例疑似手足口病病例有病毒学检测结果。共有5750例病毒检测呈阳性，其他肠道病毒引起的感染阳性率为46.7%，肠道病毒71型（EV71）为9%，柯萨奇病毒A16型（CVA16）为4.7%。研究期间手足口病的发病率大幅上升。大多数手足口病患者（87.4%）年龄在0至59个月（中位数24；范围0至59）。男性手足口病患病率（62.4%）高于女性（37.6%）。
肠道病毒感染仍然是一个重要的公共卫生问题，在中国遵义，其他肠道病毒正成为手足口病的主要病原体。
