Jensen Roxanne E, Potosky Arnold L, Reeve Bryce B, Hahn Elizabeth, Cella David, Fries James, Smith Ashley Wilder, Keegan Theresa H M, Wu Xiao-Cheng, Paddock Lisa, Moinpour Carol M
Cancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, 3300 Whitehaven Street NW, Suite 4100, Washington, DC, 20007, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Qual Life Res. 2015 Oct;24(10):2333-44. doi: 10.1007/s11136-015-0992-9. Epub 2015 May 3.
To evaluate the validity of the Patient-Reported Outcomes Measurement Information System (PROMIS) physical function measures in a diverse, population-based cancer sample.
Cancer patients 6-13 months post-diagnosis (n = 4840) were recruited for the Measuring Your Health study. Participants were diagnosed between 2010 and 2013 with non-Hodgkin lymphoma or cancers of the colorectum, lung, breast, uterus, cervix, or prostate. Four PROMIS physical function short forms (4a, 6b, 10a, and 16) were evaluated for validity and reliability across age and race-ethnicity groups. Covariates included gender, marital status, education level, cancer site and stage, comorbidities, and functional status.
PROMIS physical function short forms showed high internal consistency (Cronbach's α = 0.92-0.96), convergent validity (fatigue, pain interference, FACT physical well-being all r ≥ 0.68), and discriminant validity (unrelated domains all r ≤ 0.3) across survey short forms, age, and race-ethnicity. Known-group differences by demographic, clinical, and functional characteristics performed as hypothesized. Ceiling effects for higher-functioning individuals were identified on most forms.
This study provides strong evidence that PROMIS physical function measures are valid and reliable in multiple race-ethnicity and age groups. Researchers selecting specific PROMIS short forms should consider the degree of functional disability in their patient population to ensure that length and content are tailored to limit response burden.
评估患者报告结局测量信息系统（PROMIS）身体功能测量指标在一个多样化的、基于人群的癌症样本中的有效性。
为“测量您的健康”研究招募了诊断后6 - 13个月的癌症患者（n = 4840）。参与者在2010年至2013年期间被诊断为非霍奇金淋巴瘤或结直肠癌、肺癌、乳腺癌、子宫癌、宫颈癌或前列腺癌。对四种PROMIS身体功能简表（4a、6b、10a和16）在不同年龄和种族 - 族裔群体中的有效性和可靠性进行了评估。协变量包括性别、婚姻状况、教育水平、癌症部位和分期、合并症以及功能状态。
PROMIS身体功能简表在各调查简表、年龄和种族 - 族裔中均显示出高内部一致性（Cronbach's α = 0.92 - 0.96）、收敛效度（疲劳、疼痛干扰、FACT身体幸福感所有r≥0.68）和区分效度（不相关领域所有r≤0.3）。按人口统计学、临床和功能特征划分的已知组差异符合假设。在大多数形式上发现了功能较高个体的天花板效应。
本研究提供了强有力的证据，表明PROMIS身体功能测量指标在多个种族 - 族裔和年龄组中是有效且可靠的。选择特定PROMIS简表的研究人员应考虑其患者群体中的功能残疾程度，以确保长度和内容经过调整以限制应答负担。
