Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215-5450, USA.
Med Care. 2013 Feb;51(2):e9-15. doi: 10.1097/MLR.0b013e318222a711.
The research goals of the Cancer Care Outcomes Research and Surveillance (CanCORS) Consortium are to determine how characteristics and beliefs of patients, providers, and health care organizations influence the treatments and outcomes of individuals with newly diagnosed lung and colorectal cancers. As CanCORS results will inform national policy, it is important to know how they generalize to the United States population with these cancers.
This study assessed the representativeness of the CanCORS cohort of 10,547 patients with lung cancer (LC) or colorectal cancer (CRC) enrolled between 2003 and 2005. We compared characteristics (sex, race, age, and disease stage) with the Surveillance, Epidemiology, and End Results (SEER) population of 234,464 patients with new onset of these cancers during the CanCORS recruitment period.
The CanCORS sample is well matched to the SEER Program for both cancers. In CanCORS, 41% LC/47% CRC were female versus 47% LC/49% CRC in SEER. African American, Hispanic, and Asian cases differed by no more than 5 percentage points between CanCORS and SEER. The SEER population is slightly older, with the percentage of patients older than 75 years 33.1% LC/37.3% CRC in SEER versus 26.9% LC/29.4% in CanCORS, and also has a slightly higher proportion of early stage patients. We also found that the CanCORS cohort was representative within specific SEER regions that map closely to CanCORS sites.
This study demonstrates that the CanCORS Consortium was successful in enrolling a demographically representative sample within the CanCORS regions.
癌症护理结果研究和监测（CanCORS）联盟的研究目标是确定患者、医生和医疗机构的特征和信念如何影响新诊断出的肺癌和结直肠癌患者的治疗和结果。由于 CanCORS 的研究结果将为国家政策提供信息，因此了解它们如何推广到美国患有这些癌症的人群中非常重要。
本研究评估了 2003 年至 2005 年间招募的 10547 例肺癌（LC）或结直肠癌（CRC）患者的 CanCORS 队列的代表性。我们将特征（性别、种族、年龄和疾病阶段）与在 CanCORS 招募期间患有这些癌症的新发病例的监测、流行病学和最终结果（SEER）人群（234464 例）进行了比较。
CanCORS 样本与 SEER 计划在这两种癌症上都非常匹配。在 CanCORS 中，41%的 LC/47%的 CRC 为女性，而 SEER 中为 47%的 LC/49%的 CRC。非裔美国人、西班牙裔和亚洲人的病例在 CanCORS 和 SEER 之间相差不超过 5 个百分点。SEER 人群年龄稍大，75 岁以上患者的比例为 33.1%的 LC/37.3%的 CRC，而 CanCORS 中为 26.9%的 LC/29.4%，并且早期阶段患者的比例也略高。我们还发现，CanCORS 队列在与 CanCORS 站点密切相关的特定 SEER 区域内具有代表性。
本研究表明，CanCORS 联盟成功地在 CanCORS 区域内招募了具有代表性的人群。
