Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM U964, Université de Strasbourg, F-67404 Illkirch, France.
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM U964, Université de Strasbourg, F-67404 Illkirch, France.
Curr Opin Cell Biol. 2015 Jun;34:9-15. doi: 10.1016/j.ceb.2015.04.006. Epub 2015 May 15.
Totipotent and pluripotent cells display different degrees of cellular plasticity. After fertilization, embryonic cells transit naturally from a totipotent to a pluripotent state. Major changes in nuclear architecture, chromatin mobility and gene expression occur during this transition. In particular, nuclear architecture has recently emerged as a potential regulator of heterochromatin formation in the early embryo. Future research should address whether a causal, functional link between nuclear organization and gene regulation is a general theme during reprogramming and the formation of pluripotent cells.
全能性细胞和多能性细胞表现出不同程度的细胞可塑性。受精后，胚胎细胞自然从全能性状态转变为多能性状态。在此转变过程中，核结构、染色质运动和基因表达发生重大变化。特别是，核结构最近已成为早期胚胎异染色质形成的潜在调控因子。未来的研究应该解决核组织和基因调控之间是否存在因果关系和功能联系，这是否是重编程和多能性细胞形成过程中的一个普遍主题。
