MacDonald Ryan, Heiner Jason, Villarreal Joshua, Strote Jared
Department of Emergency Medicine, Madigan Army Medical Center, Tacoma, Washington, USA.
Division of Emergency Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA.
BMJ Case Rep. 2015 May 2;2015:bcr2015209705. doi: 10.1136/bcr-2015-209705.
Loperamide is a common over-the-counter antidiarrheal considered safe in a broad range of dosages and thought devoid of abuse potential. We describe the first case of a patient with loperamide dependence due to misuse of its opiate-like effects achieved by chronic massive oral ingestions. A 26-year-old man who was taking 800 mg of loperamide per day presented requesting detoxification referral. Loperamide has potential for euphoric effects and information on how to facilitate such effects is easily available. It is important for physicians to be aware of the potential for misuse of and dependence on loperamide, with symptoms mimicking opiate use.
洛哌丁胺是一种常见的非处方止泻药，在广泛的剂量范围内被认为是安全的，且被认为没有滥用潜力。我们描述了首例因长期大量口服滥用其阿片样作用而导致洛哌丁胺依赖的患者。一名每天服用800毫克洛哌丁胺的26岁男子前来寻求戒毒转诊。洛哌丁胺有产生欣快感的潜力，且关于如何促成这种效果的信息很容易获取。医生必须意识到洛哌丁胺存在被滥用和产生依赖的可能性，其症状与阿片类药物使用相似。
