Nakagawa Kazuko, Kajiwara Ayami
Nihon Rinsho. 2015 Apr;73(4):581-5.
Females have nearly a two-fold greater risk of developing adverse drug reactions(ADRs) than males and they are also more likely to be hospitalized due to ADR. For all drug classes, significant differences exist between the sexes, including class-specific risks and the incidence and/or severity of ADR. We herein present our results regarding the surveillance of ADR in the general population and a questionnaire-based study carried out by the Japan Pharmaceutical Association Drug Event Monitoring Project in Kumamoto Prefecture. Our findings indicate that females are prone to ADR and that high-risk agents for this population should be identified and these subjects closely monitored based on the patient characteristics.
女性发生药物不良反应（ADR）的风险几乎是男性的两倍，而且她们也更有可能因ADR而住院。对于所有药物类别，两性之间存在显著差异，包括特定类别的风险以及ADR的发生率和/或严重程度。在此，我们展示了关于普通人群中ADR监测的结果，以及由日本制药协会药物事件监测项目在熊本县开展的一项基于问卷调查的研究结果。我们的研究结果表明，女性容易发生ADR，应该识别出该人群的高风险药物，并根据患者特征对这些对象进行密切监测。
