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三尖瓣环成形术对二尖瓣脱垂修复术后三尖瓣反流、右心室功能和肺动脉高压的影响。

Impact of Concomitant Tricuspid Annuloplasty on Tricuspid Regurgitation, Right Ventricular Function, and Pulmonary Artery Hypertension After Repair of Mitral Valve Prolapse.

出版信息

J Am Coll Cardiol. 2015 May 12;65(18):1931-8. doi: 10.1016/j.jacc.2015.01.059.

Abstract

BACKGROUND

For patients undergoing mitral valve (MV) repair, the indications for and results of concomitant tricuspid annuloplasty remain controversial.

OBJECTIVES

This study was designed to compare a strategy of routine concomitant tricuspid annuloplasty for moderate tricuspid regurgitation (TR) or tricuspid annular dilation in patients undergoing degenerative MV surgery.

METHODS

Of 645 consecutive patients (mean age 57±13 years) undergoing primary repair of degenerative mitral regurgitation between 2003 and 2011, 419 (65%) underwent concomitant tricuspid annuloplasty for moderate TR and/or tricuspid annular dilation. These patients were retrospectively analyzed with longitudinal echocardiographic follow-up.

RESULTS

Patients undergoing tricuspid valve repair were older (mean age 59.2 years vs. 52.3 years), had worse right and left ventricular function and higher pulmonary artery pressures, and were more likely to have had atrial fibrillation than patients undergoing isolated MV repair (all p<0.05). No significant difference in 30-day mortality, morbidity, or permanent pacemaker requirement was seen between treatment groups. Freedom from moderate TR at 7 years was not significantly different in the 2 groups, but multivariate analysis showed that tricuspid annuloplasty was independently associated with freedom from late moderate TR (p=0.04), and was an independent predictor of recovery of right ventricular function (p=0.02).

CONCLUSIONS

In patients with moderate TR or tricuspid annular dilation who were undergoing degenerative mitral repair, concomitant tricuspid annuloplasty is safe, effective, and associated with improved long-term right-sided remodeling. Routine treatment of moderate TR or tricuspid annular dilation at the time of MV repair appears to be beneficial.

摘要

背景

对于接受二尖瓣(MV)修复的患者,中重度三尖瓣反流(TR)或三尖瓣环扩张患者同期行三尖瓣环成形术的适应证和结果仍存在争议。

目的

本研究旨在比较对行退行性 MV 手术的患者,对于中重度 TR 或三尖瓣环扩张患者行常规同期三尖瓣环成形术的策略。

方法

在 2003 年至 2011 年间连续对 645 例(平均年龄 57±13 岁)行原发性退行性二尖瓣关闭不全修复的患者中,419 例(65%)患者因中重度 TR 和/或三尖瓣环扩张而同期行三尖瓣环成形术。对这些患者进行了回顾性分析,并进行了纵向超声心动图随访。

结果

行三尖瓣瓣环成形术的患者年龄更大(平均年龄 59.2 岁 vs. 52.3 岁),右心室和左心室功能更差,肺动脉压更高,且比行单纯 MV 修复的患者更易发生心房颤动(所有 P<0.05)。两组患者在 30 天死亡率、发病率或永久性起搏器需求方面无显著差异。两组患者 7 年时中度 TR 无复发生存率无显著差异,但多变量分析显示三尖瓣瓣环成形术与晚期中度 TR 无复发生存率独立相关(P=0.04),是右心室功能恢复的独立预测因子(P=0.02)。

结论

对于行退行性 MV 修复的中重度 TR 或三尖瓣环扩张患者,同期行三尖瓣瓣环成形术是安全、有效的,与长期右心重构改善相关。在 MV 修复时常规治疗中重度 TR 或三尖瓣环扩张似乎是有益的。

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