Zwischenberger Brittany A, Bishawi Muath, Gaca Jeffrey G, Carr Keith, Glower Donald D
Division of Cardiothoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina.
Ann Thorac Surg Short Rep. 2023 Apr 5;1(3):407-410. doi: 10.1016/j.atssr.2023.03.017. eCollection 2023 Sep.
Permanent pacemaker (PPM) placement after mitral valve (MV) repair is affected by concomitant procedures, yet existing literature reports conflicting rates. We aimed to characterize the effect of concomitant operation on risk of need for postoperative PPM in patients who underwent MV repair.
A retrospective review of a prospectively maintained institutional database (1996-2020) was conducted of consecutive patients undergoing MV repair, including concomitant procedures. Multivariable regression analysis was performed to evaluate the effect of a concomitant procedure on PPM rate.
Of the 2824 patients undergoing MV repair, 6% (177/2824) required a PPM. The likelihood of PPM varied with concomitant procedures: aortic valve replacement (39/258 [15%]), coronary artery bypass grafting (86/789 [11%]), tricuspid valve (TV) repair (33/326 [10%]), and maze (27/407 [7%]). Increased PPM rate was associated with aortic valve replacement (odds ratio [OR], 2.2 [1.5-3.3]; < .001), reduced ejection fraction (OR, 1.02 [1.01-1.04]; < .001), and older age (OR, 1.04 [1.03-1.06]; < .001). Concurrent TV repair was not associated with pacemaker in patients undergoing MV repair ( = .8) or MV repair for nondegenerative mitral regurgitation ( = .9). In patients with degenerative MV disease, PPM rate increased from 1.9% (21/1133) to 10% (11/109) with concomitant TV repair ( < .001), and TV repair was associated with a 3-fold increased pacemaker rate (OR, 3.1 [1.6-5.9]; < .001).
In MV repair, risk of pacemaker with concomitant TV repair should be weighed more heavily in degenerative MV disease. Pacemaker risk should not discourage surgeons from performing TV repair in patients with nondegenerative MV disease, in patients already undergoing concomitant operation or with clinically significant tricuspid regurgitation.
二尖瓣(MV)修复术后永久性起搏器(PPM)植入受同期手术影响,但现有文献报道的发生率相互矛盾。我们旨在明确同期手术对接受MV修复患者术后PPM需求风险的影响。
对前瞻性维护的机构数据库(1996 - 2020年)进行回顾性分析,纳入连续接受MV修复的患者,包括同期手术。进行多变量回归分析以评估同期手术对PPM发生率的影响。
在2824例接受MV修复的患者中,6%(177/2824)需要植入PPM。PPM的可能性因同期手术而异:主动脉瓣置换术(39/258 [15%])、冠状动脉旁路移植术(86/789 [11%])、三尖瓣(TV)修复术(33/326 [10%])和迷宫手术(27/407 [7%])。PPM发生率增加与主动脉瓣置换术(比值比[OR],2.2 [1.5 - 3.3];P <.001)、射血分数降低(OR,1.02 [1.01 - 1.04];P <.001)和年龄较大(OR,1.04 [1.03 - 1.06];P <.001)相关。在接受MV修复的患者(P =.8)或因非退行性二尖瓣反流接受MV修复的患者(P =.9)中,同期TV修复与起搏器无关。在患有退行性MV疾病的患者中,同期TV修复时PPM发生率从1.9%(21/1133)增至10%(11/109)(P <.001),且TV修复与起搏器发生率增加3倍相关(OR,3.1 [1.6 - 5.9];P <.001)。
在MV修复中,对于退行性MV疾病,应更重视同期TV修复时的起搏器风险。对于非退行性MV疾病患者、已接受同期手术的患者或有临床显著三尖瓣反流的患者,起搏器风险不应阻碍外科医生进行TV修复。