Ludwig-Maximilians-Universität München, Genetics, Großhaderner Str. 2-4, 82152 Planegg-Martinsried, Germany.
Ludwig-Maximilians-Universität München, Genetics, Großhaderner Str. 2-4, 82152 Planegg-Martinsried, Germany.
Trends Plant Sci. 2015 Jun;20(6):351-61. doi: 10.1016/j.tplants.2015.03.016. Epub 2015 Apr 27.
Plasma membranes (PMs) are heterogeneous lipid bilayers comprising diverse subdomains. These sites can be labeled by various proteins in vivo and may serve as hotspots for signal transduction. They are found at apical, basal, and lateral membranes of polarized cells, at cell equatorial planes, or almost isotropically distributed throughout the PM. Recent advances in imaging technologies and understanding of mechanisms that allow proteins to target specific sites in PMs have provided insights into the dynamics and complexity of their specific segregation. Here we present a comprehensive overview of the different types of membrane microdomain and describe the molecular modes that determine site-directed targeting of membrane-resident proteins at the PM.
质膜（PM）是由不同亚域组成的不均匀脂质双层。这些位点可以在体内被各种蛋白质标记，并且可能作为信号转导的热点。它们存在于极化细胞的顶膜、基底膜和侧膜、细胞赤道平面，或者几乎在整个 PM 中均匀分布。成像技术的最新进展和对允许蛋白质靶向 PM 中特定位点的机制的理解，为它们特定隔离的动态和复杂性提供了深入了解。在这里，我们全面概述了不同类型的膜微区，并描述了决定膜驻留蛋白在 PM 上靶向特定位点的分子模式。
