Chair of Microbiology, Jagiellonian University Medical College, Krakow, Poland.
Chair of Microbiology, Jagiellonian University Medical College, Krakow, Poland.
Int J Infect Dis. 2015 Jun;35:87-92. doi: 10.1016/j.ijid.2015.04.017. Epub 2015 Apr 29.
The objectives of this study were to analyze the impact of infections on prolonging hospital stay with consideration of underlying risk factors and determining the mortality rates and its association with infections.
An electronic database developed from a continuous prospective targeted infection surveillance program was used in the study. Data were collected from 2009 to 2012 in five Polish tertiary academic neonatal intensive care units (NICUs). The length of stay (LOS) of 2,003 very low birth weight (VLBW) neonates was calculated as the sum of the number of days since birth until death or until reaching a weight of 1,800g.
The median LOS for neonates with infections was twice as high as for neonates without infection. LOS was significantly affected by the overall general condition of the neonate, as expressed by both gestational age and birth weight as well as by the Clinical Risk Index for Babies (CRIB) score; another independent factor was presence of at least one infection. Risk of in-hospital mortality was significantly increased by male sex and vaginal birth and was lower among breastfed neonates. Deaths were significantly more frequent in neonates without infection.
The general condition of VLBW infants statistically increase both their risk of mortality and LOS; this is in contrast to the presence of infection, which significantly prolonged LOS only.
本研究旨在分析感染对延长住院时间的影响，并考虑潜在的风险因素，同时确定死亡率及其与感染的关系。
本研究使用了一个从连续前瞻性目标感染监测计划中开发的电子数据库。数据收集自 2009 年至 2012 年期间波兰五所三级学术新生儿重症监护病房（NICU）的 2003 例极低出生体重（VLBW）新生儿。住院时间（LOS）的计算方法为自出生起至死亡或体重达到 1800 克的天数总和。
感染组新生儿的 LOS 中位数是无感染组的两倍。LOS 显著受到新生儿整体一般状况的影响，由胎龄和出生体重以及婴儿临床风险指数（CRIB）评分表示；另一个独立因素是至少存在一种感染。男性性别、阴道分娩和母乳喂养会显著增加住院期间的死亡风险，而感染则显著延长 LOS。无感染的新生儿死亡率显著降低。
VLBW 婴儿的一般状况会增加其死亡风险和 LOS，而感染只会显著延长 LOS。
