Department of Medical Education, Ditmanson Medical Foundation, Chia-Yi Christian Hospital, Chia-Yi, Taiwan.
Department of Optometry / Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung, Taiwan.
BMJ Open. 2021 Dec 23;11(12):e046891. doi: 10.1136/bmjopen-2020-046891.
Both physical diseases such as infection and chronic pain and psychological disorders such as depression have been associated with herpes zoster (HZ) reactivation. However, the relationship between de Quervain syndrome (DQS), a painful tenosynovitis and HZ remains unclear. We investigated whether DQS increases the risk of HZ reactivation.
A retrospective population-based cohort study.
Taiwan.
We used a subset of Taiwan's National Health Insurance Research Database, the Longitudinal Health Insurance Database which contains the registration files and original claims data of 1 million randomly selected individuals from the National Health Insurance programme. The case group in this study comprised patients newly diagnosed with DQS between 2000 and 2012. Individuals without DQS comprised the control group. Cases and controls were 1:1 matched by age, sex and index year (defined as the year of DQS diagnosis).
Approximately 55% of the participants were ≤49 years. Most participants were women (77%). The incidence rate of HZ in the DQS group was 8.39 per 1000 person years. After adjustments for age, sex and comorbidities, patients with DQS had a 1.30 times higher risk of HZ reactivation than the control group. Stratification analysis revealed taht DQS increases the HZ risk in individuals ≤64 years, women, and patients without comorbidities.
DQS is associated with an increased risk of HZ. Clinicians should be aware of this risk when dealing with patients with DQS, particularly in young adults.
感染和慢性疼痛等躯体疾病以及抑郁等心理障碍与带状疱疹（HZ）再激活有关。然而，痛性腱鞘炎（DQS）与 HZ 之间的关系尚不清楚。我们研究了 DQS 是否会增加 HZ 再激活的风险。
回顾性基于人群的队列研究。
中国台湾。
我们使用了台湾全民健康保险研究数据库的一个子集，即纵向健康保险数据库，其中包含了 100 万随机选择的参加国家健康保险计划的个体的登记文件和原始理赔数据。本研究中的病例组包括 2000 年至 2012 年间新诊断为 DQS 的患者。无 DQS 的个体为对照组。病例和对照组按年龄、性别和指数年（定义为 DQS 诊断的年份）进行 1:1 匹配。
约 55%的参与者年龄≤49 岁。大多数参与者为女性（77%）。DQS 组的 HZ 发生率为 8.39/1000 人年。调整年龄、性别和合并症后，DQS 患者发生 HZ 再激活的风险比对照组高 1.30 倍。分层分析显示，在≤64 岁、女性和无合并症的个体中，DQS 增加了 HZ 的风险。
DQS 与 HZ 风险增加有关。临床医生在处理 DQS 患者时应注意这一风险，尤其是在年轻成年人中。
