腺嘌呤密码子 DNA：N6-甲基腺嘌呤的第二生命。

An Adenine Code for DNA: A Second Life for N6-Methyladenine.

机构信息

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain; Department of Physiological Sciences II, School of Medicine, University of Barcelona, 08036 Barcelona, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Catalonia, Spain.

出版信息

Cell. 2015 May 7;161(4):710-3. doi: 10.1016/j.cell.2015.04.021. Epub 2015 Apr 30.

DOI:10.1016/j.cell.2015.04.021

PMID:25936836

Abstract

DNA N6-methyladenine (6mA) protects against restriction enzymes in bacteria. However, isolated reports have suggested additional activities and its presence in other organisms, such as unicellular eukaryotes. New data now find that 6mA may have a gene regulatory function in green alga, worm, and fly, suggesting m6A as a potential "epigenetic" mark.

摘要

DNA N6-甲基腺嘌呤（6mA）在细菌中可抵御限制酶的作用。然而，一些零星报道暗示了其在其他生物体（如单细胞真核生物）中的额外功能和存在。新的数据发现 6mA 可能在绿藻、蠕虫和果蝇中有基因调控功能，这表明 m6A 可能是一种潜在的“表观遗传”标记。