真核生物中的 DNA N6-甲基腺嘌呤：功能表观遗传标记还是旁观者？
DNA N-methyladenine in metazoans: functional epigenetic mark or bystander?
机构信息
Department of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois, USA. Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois, USA. Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, USA.
出版信息
Nat Struct Mol Biol. 2017 Jun 6;24(6):503-506. doi: 10.1038/nsmb.3412.
The DNA-adenine modification N-methyladenine (6mA), initially thought to be mainly restricted to prokaryotes and certain unicellular eukaryotes, has recently been found in metazoans. Proposed functions vary from gene activation to transposon suppression. However, since most metazoan genomes possess 5-methylcytosine (5mC) as a dominant epigenetic mark, it raises the question of why 6mA is required. This Perspective summarizes the latest discoveries and suggests potential functional roles for 6mA in metazoan genomes.
DNA-腺嘌呤修饰 N6-甲基腺嘌呤（6mA），最初被认为主要局限于原核生物和某些单细胞真核生物中，最近在后生动物中被发现。提出的功能从基因激活到转座子抑制不等。然而，由于大多数后生动物基因组具有 5-甲基胞嘧啶（5mC）作为主要的表观遗传标记，因此提出了为什么需要 6mA 的问题。本观点总结了最新的发现，并提出了 6mA 在后生动物基因组中潜在的功能作用。
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