Meyers Jason D, Jay Patrick Y, Rentschler Stacey
Department of Medicine, Washington University School of Medicine, St Louis, MO; Department of Biomedical Engineering, Washington University, St Louis, MO.
Department of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St Louis, MO; Department of Genetics, Washington University School of Medicine, St Louis Children's Hospital, St Louis, MO.
Trends Cardiovasc Med. 2016 Jan;26(1):14-20. doi: 10.1016/j.tcm.2015.03.015. Epub 2015 Apr 1.
Diseases of the cardiac conduction system can be debilitating and deadly. Electronic pacemakers are incredibly effective in the treatment of sinus and AV node dysfunction, yet there remain important limitations and complications. These issues have driven interest in the development of a biological pacemaker. Here, we review experimental progress in animal models and discuss future directions, with a focus on reprogramming endogenous cells in the heart to treat defects of rhythm and conduction.
心脏传导系统疾病可能使人虚弱甚至致命。电子起搏器在治疗窦房结和房室结功能障碍方面非常有效,但仍存在重要的局限性和并发症。这些问题激发了人们对生物起搏器研发的兴趣。在此,我们回顾动物模型中的实验进展并讨论未来方向,重点是对心脏内源性细胞进行重编程以治疗节律和传导缺陷。